Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN, United States.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States.
Front Endocrinol (Lausanne). 2022 Jun 13;13:904004. doi: 10.3389/fendo.2022.904004. eCollection 2022.
Diabetes mellitus, a disease that affects nearly 536.6 million people worldwide, is characterized by the death or dysfunction of insulin-producing beta cells of the pancreas. The beta cells are found within the islets of Langerhans, which are composed of multiple hormone-producing endocrine cells including the alpha (glucagon), delta (somatostatin), PP (pancreatic polypeptide), and epsilon (ghrelin) cells. There is direct evidence that physical and paracrine interactions between the cells in the islet facilitate and support beta cell function. However, communication between endocrine and exocrine cells in the pancreas may also directly impact beta cell growth and function. Herein we review literature that contributes to the view that "crosstalk" between neighboring cells within the pancreas influences beta cell growth and function and the maintenance of beta cell health.
糖尿病是一种影响全球近 5.366 亿人的疾病，其特征是胰腺产生胰岛素的β细胞死亡或功能障碍。β细胞位于胰岛内，胰岛由多种激素分泌细胞组成，包括α（胰高血糖素）、δ（生长抑素）、PP（胰多肽）和ε（胃饥饿素）细胞。有直接证据表明，胰岛内细胞之间的物理和旁分泌相互作用有助于并支持β细胞功能。然而，胰腺内分泌和外分泌细胞之间的通讯也可能直接影响β细胞的生长和功能。本文综述了有助于“细胞间串扰”影响胰腺内β细胞生长和功能以及β细胞健康维持的文献。
