经动脉放射性栓塞治疗结直肠癌肝转移后血管生成因子水平升高可能预示预后不良。

Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis.

作者信息

Soydal Çiğdem, Araz Mine, Durmaz Mustafa, Özkan Elgin, Ergüder Berrin İmge, Küçük Nuriye Özlem, Bilgiç Sadık, Elhan Atilla Halil, Geçim İbrahim Ethem

机构信息

Ankara University Faculty of Medicine, Department of Nuclear Medicine, Ankara, Turkey.

Ankara University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey.

出版信息

Mol Imaging Radionucl Ther. 2022 Jun 27;31(2):114-122. doi: 10.4274/mirt.galenos.2022.73636.

OBJECTIVES

To analyze the change in circulating angiogenic factor levels after transarterial radioembolization (TARE) for colorectal cancer liver metastases (CRCLMs) and its prognostic significance.

METHODS

Blood samples immediately before TARE and on 1 day, 1 week and 6 weeks after were collected for angiogenic factor analysis in 23 patients.

RESULTS

Patients with elevated serum basic fibroblast growth factor and platelet-derived growth factor levels in the 1 week and vascular endothelial growth factor (VEGF) levels in the 6 week after TARE had significantly shorter median overall survival (OS) times.

CONCLUSION

Some early increases in serum angiogenic factor levels and in serum VEGF in the 6 week after TARE for CRCLMs are related to short OS and progression-free survival.