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基于铁嗪和 CUPRAC 方法的几种单萜与铁、铜离子相互作用的初步研究。

Interactions of Selected Monoterpenes with Iron and Copper Ions Based on Ferrozine and CUPRAC Methods - the Preliminary Studies.

机构信息

Medical University of Lublin, Department of Inorganic Chemistry, 20-059, Lublin, Poland.

出版信息

Chem Biodivers. 2022 Aug;19(8):e202200461. doi: 10.1002/cbdv.202200461. Epub 2022 Jul 12.

Abstract

Secondary plant metabolites are chemical compounds produced by plants through a variety of metabolic pathways. It is known that these compounds, among others, monoterpenes, are characterized by holding valuable pro-health activities when consumed or applied. Taking into account the development of civilizational diseases, eating foods enriched with compounds such as the monoterpenes is highly recommended. Good sources of such health-promoting food items include common fruits and vegetables, seed sources and plant parts used to enhance flavour such as spices. It is known that monoterpene compounds instigate or contribute to a variety of biological activities. It is known that the compounds can scavenge free radicals, reduce Fe(III) and inhibit AChE which are considered as possible anti-neurodegenerative activities. The aim of the presented study was to determinate another activity of selected monoterpenes, namely towards reducing and chelating Cu(II) and Fe(II), respectively. The assays were based on colorimetric CUPRAC and ferrozine-based methods. Study results explicitly indicated chelation and reduction activities of the selected monoterpenes. These properties considerably support the benefits of consuming plants rich in these compounds.

摘要

次生代谢产物是植物通过多种代谢途径产生的化学化合物。已知这些化合物,包括单萜类化合物,在食用或应用时具有宝贵的促进健康的活性。考虑到文明病的发展,强烈建议食用富含单萜等化合物的食物。这类具有促进健康作用的食物的良好来源包括常见的水果和蔬菜、种子来源以及用于增强风味的植物部分,如香料。已知单萜类化合物会引发或有助于多种生物活性。已知这些化合物可以清除自由基、还原 Fe(III)并抑制 AChE,这些被认为是可能的抗神经退行性活动。本研究的目的是确定所选单萜类化合物的另一种活性,即分别还原和螯合 Cu(II)和 Fe(II)。测定基于比色 CUPRAC 和基于亚铁嗪的方法。研究结果明确表明了所选单萜类化合物的螯合和还原活性。这些特性极大地支持了食用富含这些化合物的植物的益处。

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