Department of International Health, Human Nutrition Program, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Infect Dis Poverty. 2022 Jun 30;11(1):76. doi: 10.1186/s40249-022-00999-5.
Antibiotics have become a mainstay of healthcare in the past century due to their activity against pathogens. This manuscript reviews the impact of antibiotic use on the intestinal microbiota in the context of mass drug administration (MDA). The importance of the gut microbiota to human metabolism and physiology is now well established, and antibiotic exposure may impact host health via collateral effects on the microbiota and its functions. To gain further insight into how gut microbiota respond to antibiotic perturbation and the implications for public health, factors that influence the impact of antibiotic exposure on the microbiota, potential health outcomes of antibiotic-induced microbiota alterations, and strategies that have the potential to ameliorate these wider antibiotic-associated microbiota perturbations are also reviewed.
抗生素在过去一个世纪因其对病原体的作用而成为医疗保健的主要手段。本文综述了在大规模药物治疗（MDA）背景下抗生素使用对肠道微生物组的影响。肠道微生物组对人类代谢和生理学的重要性现在已经得到充分证实，抗生素暴露可能通过对微生物组及其功能的间接影响来影响宿主健康。为了更深入地了解肠道微生物组对抗生素干扰的反应及其对公共卫生的影响，还综述了影响抗生素暴露对微生物组影响的因素、抗生素诱导的微生物组改变的潜在健康后果，以及有潜力改善这些更广泛的抗生素相关微生物组扰动的策略。
