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使用牛初乳治疗牙周炎患者垂直骨缺损的骨再生

Bone Regeneration in Vertical Osseous Defect in Periodontitis Patients using Bovine Colostrum.

作者信息

Ravishankar P L, Guruprasath Preethikaa, Vangipuram Padmaja, Vaidya Jasmine, Visithiriyan G, Raj A Thirumal, Bhandi Shilpa, Patil Shankargouda, Ghosh Snehashish

机构信息

Department of Periodontics, SRM Kattankulathur Dental College, Potheri, 603203, Tamil Nadu, India.

Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai 600130, India.

出版信息

Case Rep Dent. 2022 Jun 21;2022:4183552. doi: 10.1155/2022/4183552. eCollection 2022.

DOI:10.1155/2022/4183552
PMID:35774248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9239770/
Abstract

BACKGROUND

The treatment plan for periodontitis may include both nonsurgical and surgical phases. During surgical procedures, bone grafts and barrier membranes were used after degranulation in order to achieve healing. Colostrum is one of the materials that is composed of bioactive components which has either osteoinductive or regenerative potential.

AIM

The aim of the present study is to evaluate the effectiveness of bovine colostrum as bone regeneration material in periodontitis. . Clinical periodontal parameters, including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI), were evaluated. Patients who were diagnosed with localised periodontitis were selected. Three patients presenting vertical defect at buccal sites were treated with bovine colostrum. Following nonsurgical treatment, flap surgery was performed using bovine colostrum. After 6 months, favourable clinical and radiographical improvements were obtained.

CONCLUSION

All cases showed reduction in PD; these findings suggest that the bovine colostrum could favour periodontal regeneration. The clinical significance is that bovine colostrum is cost effective and easily available and enhances bone regeneration. It can therefore be used as an alternative to bone grafts during periodontal surgery.

摘要

背景

牙周炎的治疗方案可能包括非手术和手术阶段。在手术过程中，清创后使用骨移植材料和屏障膜以促进愈合。初乳是一种由具有骨诱导或再生潜力的生物活性成分组成的物质。

目的

本研究的目的是评估牛初乳作为牙周炎骨再生材料的有效性。评估了包括探诊深度（PD）、临床附着水平（CAL）、探诊出血（BOP）和菌斑指数（PI）在内的临床牙周参数。选择被诊断为局限性牙周炎的患者。3例颊侧出现垂直缺损的患者接受了牛初乳治疗。在非手术治疗后，使用牛初乳进行翻瓣手术。6个月后，获得了良好的临床和影像学改善。

结论

所有病例的PD均降低；这些发现表明牛初乳可能有利于牙周再生。其临床意义在于牛初乳具有成本效益且易于获取，并能促进骨再生。因此，在牙周手术中它可作为骨移植材料的替代品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ec/9239770/b2261bfcc1e9/CRID2022-4183552.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ec/9239770/dc7c6774825d/CRID2022-4183552.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ec/9239770/18f8fda5ed58/CRID2022-4183552.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ec/9239770/b63fb02c9440/CRID2022-4183552.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ec/9239770/4ac530c60fcb/CRID2022-4183552.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ec/9239770/b2261bfcc1e9/CRID2022-4183552.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ec/9239770/dc7c6774825d/CRID2022-4183552.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ec/9239770/18f8fda5ed58/CRID2022-4183552.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ec/9239770/b63fb02c9440/CRID2022-4183552.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ec/9239770/4ac530c60fcb/CRID2022-4183552.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8ec/9239770/b2261bfcc1e9/CRID2022-4183552.005.jpg

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