APC Microbiome Ireland, College of Medicine and Health, University College Cork, T12 K8AF Cork, Ireland.
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK.
Nutrients. 2021 Oct 26;13(11):3798. doi: 10.3390/nu13113798.
The health benefits of bovine colostrum have extensively been studied, including immune effects mediated by immunoglobulins, lactoferrin, and casein, as well as by certain growth factors. Some of these effects are not directly related to the absorption of proteins from the intestinal tract. The ingestion of BC can modulate the function of subsets of lymphocytes, macrophages, and dendritic cells and increase regulatory cytokines such as interleukin 10. In this review, we predominantly focused on evidence from human studies on benefits in health and disease. This review highlights that clear evidence of the prevention of infectious diseases in pre-term infants such as necrotizing enterocolitis, neonatal sepsis or prevention of cancer metastasis is lacking. This is clearly an area where translational science has to be strengthened, taking the considerable evidence from numerous ex vivo studies on cells and tissues and from animal interventions. The review focuses predominantly on human data.
牛初乳的健康益处已经得到了广泛的研究，包括免疫球蛋白、乳铁蛋白和酪蛋白介导的免疫作用，以及某些生长因子的作用。其中一些作用与肠道吸收蛋白质无关。牛初乳的摄入可以调节淋巴细胞、巨噬细胞和树突状细胞亚群的功能，并增加调节性细胞因子，如白细胞介素 10。在这篇综述中，我们主要关注来自人类研究的健康和疾病获益的证据。这篇综述强调，目前缺乏明确的证据表明牛初乳可以预防早产儿的传染病，如坏死性小肠结肠炎、新生儿败血症或预防癌症转移。这显然是一个需要加强转化科学的领域，需要利用大量来自细胞和组织的体外研究以及动物干预的证据。本综述主要侧重于人类数据。
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