Katano Atsuto, Minamitani Masanari, Nakagawa Keiichi, Yamashita Hideomi
Radiology, The University of Tokyo Hospital, Tokyo, JPN.
Radiation Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, JPN.
Cureus. 2022 May 25;14(5):e25333. doi: 10.7759/cureus.25333. eCollection 2022 May.
The incidence rate of spontaneous remission of malignant cancer is very low. Reports on spontaneous remission in advanced prostate cancer are extremely limited. Our patient was treated with androgen deprivation therapy, local radiotherapy, and surgical castration at the initial diagnosis. Approximately nine years after treatment, he experienced a rise in serum prostate-specific antigen level and relapse of obturator lymph node adenopathy. Initially, androgen deprivation therapy was reinitiated, which resulted in castration-resistant prostate cancer. Although androgen deprivation therapy was discontinued, spontaneous remission of recurrent lymph node and spontaneous reduction in serum prostate-specific antigen level was seen. There was no sign of radiological recurrence for over eight years without prostate cancer treatment.
恶性肿瘤的自发缓解率非常低。关于晚期前列腺癌自发缓解的报道极为有限。我们的患者在初诊时接受了雄激素剥夺治疗、局部放疗和手术去势。治疗后约九年，他的血清前列腺特异性抗原水平升高，闭孔淋巴结病复发。最初重新开始雄激素剥夺治疗，导致了去势抵抗性前列腺癌。尽管停止了雄激素剥夺治疗，但仍出现了复发性淋巴结的自发缓解以及血清前列腺特异性抗原水平的自发降低。在未进行前列腺癌治疗的情况下，超过八年没有影像学复发的迹象。
