Lopes-Rocha Lígia, Hernandez Clara, Gonçalves Virgínia, Pinho Teresa, Tiritan Maria Elizabeth
UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, Gandra, Portugal.
TOXRUN-Toxicology Research Unit, University Institute of Health Sciences (IUCS), CESPU, Gandra, Portugal.
Crit Rev Anal Chem. 2024;54(3):653-668. doi: 10.1080/10408347.2022.2093097. Epub 2022 Jul 1.
Knowing the impacts of bisphenol A (BPA) on human health, this systematic review aimed to gather the analytical methods for the quantification of BPA release of BPA in dental materials in and (biological fluids) studies. A brief critical discussion of the impacts of BPA on human health and the possible association with BPA in dental materials was also presented. The research was carried out by three independent researchers, (according to PRISMA guidelines) in PUBMED and SCOPUS databases, by searching for specific keywords and articles published between January 2011 and February 2022. Seventeen articles met the eligibility criteria and were included in this systematic review: 10 and 7 . In studies, the highest amounts of BPA released were from flowable to conventional resins, followed by resin-modified glass ionomer. In contrast, the smallest amount was released from "BPA-free" composites and CAD-CAM blocks. Regarding studies, a higher concentration of BPA were found in saliva than urine or blood. The best analytical method for trace quantifying BPA is LC-MS/MS (Liquid Chromatography with Tandem Mass Spectrometry) due to its selectivity, low quantification limits, and the unequivocal identification. However, further studies are required to develop faster and more sensitive methods, in order to obtain more reliable results.
鉴于双酚A（BPA）对人体健康的影响，本系统评价旨在收集在体内和体外（生物流体）研究中用于定量牙科材料中BPA释放量的分析方法。本文还简要批判性地讨论了BPA对人体健康的影响以及与牙科材料中BPA的可能关联。该研究由三名独立研究人员按照PRISMA指南在PUBMED和SCOPUS数据库中进行，通过搜索2011年1月至2022年2月期间发表的特定关键词和文章。十七篇文章符合纳入标准并被纳入本系统评价：10篇体内研究和7篇体外研究。在体内研究中，释放BPA量最高的是可流动树脂至传统树脂，其次是树脂改性玻璃离子水门汀。相比之下，“不含BPA”的复合材料和CAD-CAM块释放的量最小。关于体外研究，在唾液中发现的BPA浓度高于尿液或血液。由于其选择性、低定量限和明确的鉴定能力，用于痕量定量BPA的最佳分析方法是液相色谱-串联质谱法（LC-MS/MS）。然而，需要进一步研究以开发更快、更灵敏的方法，以便获得更可靠的结果。
