Neuroscience Research Group (NRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran; School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Science, Iran; School of Medicine, Shahid Beheshti University of Medical Science, Iran.
J Clin Neurosci. 2022 Aug;102:101-108. doi: 10.1016/j.jocn.2022.06.017. Epub 2022 Jun 28.
There were concerns about the psychological outcomes of coronavirus disease from the beginning of the pandemic. Parkinson's disease (PD) patients seem to be more vulnerable to mental health disorders like stress, depression, anxiety, or worsening quality of life during COVID-19 lockdown. We aimed to conduct a systematic review to investigate the psychological outcomes of COVID-19 among the PD population.
A systematic search was conducted using PubMed, Scopus, and Web of Science. We included original studies which reported the psychological impact of COVID-19 in the PD population with a minimum of 10 cases.
After the screening, 21 studies with a total of 5236 PD cases were included in our qualitative synthesis. Depression, anxiety, and to less extent sleep disorders and apathy are the most studied psychological outcomes. Most of the studies indicated that the severity or the prevalence of psychiatric disturbance increased due to the COVID-19 pandemic in PD patients. The prevalence of anxiety was 14% to 66.5%, while depression was reported in 0% to 50% of PD patients during and after the pandemic. Also, sleep problems were reported in 35.4% to 68.9% of PD patients.
Considering the overall trend of increment in the severity of the main psychological outcomes observed in the present systematic review, it is suggested that future studies conduct a more accurate analysis of the prevalence, severity, and associated pathology of psychological outcomes of COVID-19 in PD patients.
从疫情开始，就有人对冠状病毒病的心理后果表示担忧。帕金森病（PD）患者在 COVID-19 封锁期间似乎更容易出现心理健康障碍，如压力、抑郁、焦虑或生活质量下降。我们旨在进行一项系统评价，以调查 COVID-19 对 PD 人群的心理影响。
使用 PubMed、Scopus 和 Web of Science 进行系统搜索。我们纳入了至少报告了 COVID-19 对 PD 人群心理影响的 10 例以上病例的原始研究。
经过筛选，21 项研究共纳入了 5236 例 PD 病例，进行了定性综合分析。抑郁、焦虑，以及在较小程度上的睡眠障碍和冷漠，是研究最多的心理结果。大多数研究表明，由于 COVID-19 大流行，PD 患者的精神障碍严重程度或患病率增加。焦虑的患病率为 14%至 66.5%，而抑郁在大流行期间和之后报告的 PD 患者中占 0%至 50%。此外，35.4%至 68.9%的 PD 患者报告存在睡眠问题。
考虑到本系统评价中观察到的主要心理结果严重程度总体呈递增趋势，建议未来的研究更准确地分析 COVID-19 在 PD 患者中的心理结果的患病率、严重程度和相关病理。
