Science Center for Future Foods, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China.
School of Biotechnology and Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China.
Bioresour Technol. 2022 Sep;360:127538. doi: 10.1016/j.biortech.2022.127538. Epub 2022 Jun 28.
Flavonoids are natural plant products with important nutritional value, health-promoting benefits, and therapeutic potential. The use of microbial cell factories to generate flavonoids is an appealing option. The microbial biosynthesis of flavonoids is compared to the classic plant extract approach in this review, and the pharmaceutical applications were presented. This paper summarize approaches for effective flavonoid biosynthesis from microorganisms, and discuss the challenges and prospects of microbial flavonoid biosynthesis. Finally, the barriers and strategies for industrial bio-production of flavonoids are highlighted. This review offers guidance on how to create robust microbial cell factories for producing flavonoids and other relevant chemicals.
类黄酮是具有重要营养价值、促进健康益处和治疗潜力的天然植物产物。利用微生物细胞工厂生产类黄酮是一种很有吸引力的选择。本文比较了微生物生物合成类黄酮与经典的植物提取物方法，并介绍了其在药物方面的应用。本文总结了从微生物中有效生物合成类黄酮的方法，并讨论了微生物类黄酮生物合成的挑战和前景。最后，强调了类黄酮工业生物生产的障碍和策略。本文为如何构建生产类黄酮和其他相关化学品的稳健微生物细胞工厂提供了指导。
