Medical Laboratory Techniques, Toros University Vocational School of Health Services, Mersin, Turkey.
Andrology Laboratory, Adana City Training and Research Hospital, Adana, Turkey.
J Med Virol. 2022 Nov;94(11):5201-5205. doi: 10.1002/jmv.27971. Epub 2022 Jul 29.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded RNA virus that causes many diseases such as respiratory diseases, cardiovascular diseases, and gastrointestinal diseases. Although it has been shown that the angiotensin-converting enzyme 2 receptor, which has a high affinity for the SARS-CoV-2 is mostly expressed in the lungs, it is also expressed especially in the cells of the testicular tissue. Although there are studies showing the effect of SARS-CoV-2 on spermatogenesis, the effects of COVID-19 on sperm count, motility, and morphology are still unclear. The aim of this study is to investigate changes in sperm quality in men who had recovered and never had COVID-19, therefore semen samples were analyzed from all individuals in the patient and control groups aged 20-50 years who agreed to participate in the study and voluntary in SBU Ministry of Health Adana City Training and Research Hospital. (Toros University Ethics Committee Decision Number: 1433, Date: April 15, 2021) (Adana Provincial Health Directorate Ethics Commission Decision dated May 27, 2021/5). Two groups were selected (100 men had and recovered from COVID-19, and 100 men never had COVID-19) spermiograms from both groups were analyzed in accordance with the World Health Organization standards. The sperm concentration of the COVID-19 negative group was significantly higher than those in the COVID-19 positive group. No statistically significant difference was detected between the groups for sperm motility and morphology. It was observed that men with COVID-19 had decreased sperm concentrations suggesting that COVID-19 may have a negative effect on male fertility. However, in the long term, more comprehensive studies with a large sample size are needed to understand better the changes in sperm concentration.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是一种单链 RNA 病毒，可引起多种疾病，如呼吸道疾病、心血管疾病和胃肠道疾病。尽管已经表明，对 SARS-CoV-2 具有高亲和力的血管紧张素转换酶 2 受体主要在肺部表达，但它也特别在睾丸组织细胞中表达。虽然有研究表明 SARS-CoV-2 对精子发生有影响，但 COVID-19 对精子计数、活力和形态的影响仍不清楚。本研究旨在研究曾感染和从未感染过 COVID-19 的男性精子质量的变化，因此分析了来自同意参加研究的患者和对照组中所有年龄在 20-50 岁的个体的精液样本，且均为自愿参加 SBU 卫生部阿达纳市培训和研究医院。（托罗斯大学伦理委员会决定号：1433，日期：2021 年 4 月 15 日）（阿达纳省卫生署伦理委员会决定日期：2021 年 5 月 27 日/5 号）。选择了两组（100 名曾感染过 COVID-19 并已康复的男性，100 名从未感染过 COVID-19 的男性），按照世界卫生组织的标准对两组的精子进行了分析。COVID-19 阴性组的精子浓度明显高于 COVID-19 阳性组。两组的精子活力和形态无统计学差异。观察到 COVID-19 男性的精子浓度降低，这表明 COVID-19 可能对男性生育能力产生负面影响。然而，从长远来看，需要进行更多的具有更大样本量的综合研究，以更好地了解精子浓度的变化。
