Faculty of Medicine, Dalhousie Medicine New Brunswick, Saint John, New Brunswick, Canada.
Faculty of Kinesiology, University of New Brunswick, Fredericton, New Brunswick, Canada.
Sci Rep. 2022 Jul 1;12(1):11146. doi: 10.1038/s41598-022-15169-8.
This retrospective study of prospectively collected data aimed to identify unique pain and disability trajectories in patients following lumbar discectomy surgery. Patients of this study population presented chiefly with lumbar radiculopathy and underwent discectomy surgery from thirteen sites enrolled in the CSORN registry. Outcome variables of interest included numeric rating scales for leg/back pain and modified Oswestry disability index scores at baseline, 3, 12, and 24 months post-operatively. Latent class growth analysis was used to identify distinct courses in each outcome. Data from 524 patients revealed three unique trajectories for leg pain (excellent = 18.4%, good = 55.4%, poor = 26.3%), disability (excellent = 59.7%, fair = 35.6%, poor = 4.7%) and back pain (excellent = 13.0%, good = 56.4%, poor = 30.6%). Construct validity was supported by statistically significant differences in the proportions of patients attaining the criteria for minimal important change (MIC; 30%) or clinical success in disability (50% or Oswestry score ≤ 22) (p < 0.001). The variable proportions of patients belonging to poor outcome trajectories shows a disconnect between improved disability and persistence of pain. It will be beneficial to incorporate this information into the realm of patient expectation setting in concert with future findings of potential factors predictive of subgroup membership.
本回顾性研究对前瞻性收集的数据进行了分析,旨在确定腰椎间盘切除术患者的独特疼痛和残疾轨迹。该研究人群的患者主要表现为腰椎神经根病,并在 CSORN 注册中心的 13 个地点接受了椎间盘切除术。感兴趣的结局变量包括基线、术后 3 个月、12 个月和 24 个月时腿部/背部疼痛的数字评分量表和改良 Oswestry 残疾指数评分。潜在类别增长分析用于确定每个结局的独特轨迹。来自 524 名患者的数据显示腿部疼痛有三种独特的轨迹(优=18.4%,良=55.4%,差=26.3%)、残疾(优=59.7%,良=35.6%,差=4.7%)和背部疼痛(优=13.0%,良=56.4%,差=30.6%)。统计学上显著差异支持构效关系的合理性,即在达到最小重要变化(MIC;30%)或残疾临床成功(50%或 Oswestry 评分≤22)标准的患者比例方面存在差异(p<0.001)。属于不良结局轨迹的患者比例的变化表明,残疾的改善与疼痛的持续存在之间存在脱节。在与潜在因素预测亚组成员关系的未来研究结果相结合的情况下,将这些信息纳入患者期望设定领域将是有益的。