Lambuk Lidawani, Suhaimi Nurfatihah Azlyna Ahmad, Sadikan Muhammad Zulfiqah, Jafri Azliana Jusnida Ahmad, Ahmad Suhana, Nasir Nurul Alimah Abdul, Uskoković Vuk, Kadir Ramlah, Mohamud Rohimah
Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kota Bharu, Kelantan, Malaysia.
Centre for Neuroscience Research (NeuRon), Faculty of Medicine, Universiti Teknologi MARA, 47000, Sungai Buloh, Selangor, Malaysia.
Eye Vis (Lond). 2022 Jul 2;9(1):26. doi: 10.1186/s40662-022-00298-y.
Recently, a considerable amount of literature has emerged around the theme of neuroinflammation linked to neurodegeneration. Glaucoma is a neurodegenerative disease characterized by visual impairment. Understanding the complex neuroinflammatory processes underlying retinal ganglion cell loss has the potential to improve conventional therapeutic approaches in glaucoma. Due to the presence of multiple barriers that a systemically administered drug has to cross to reach the intraocular space, ocular drug delivery has always been a challenge. Nowadays, studies are focused on improving the current therapies for glaucoma by utilizing nanoparticles as the modes of drug transport across the ocular anatomical and physiological barriers. This review offers some important insights on the therapeutic advancements made in this direction, focusing on the use of nanoparticles loaded with anti-inflammatory and neuroprotective agents in the treatment of glaucoma. The prospect of these novel therapies is discussed in relation to the current therapies to alleviate inflammation in glaucoma, which are being reviewed as well, along with the detailed molecular and cellular mechanisms governing the onset and the progression of the disease.
最近，围绕与神经退行性变相关的神经炎症这一主题，出现了大量文献。青光眼是一种以视力损害为特征的神经退行性疾病。了解视网膜神经节细胞丢失背后复杂的神经炎症过程，有可能改进青光眼的传统治疗方法。由于全身给药的药物必须穿过多个屏障才能到达眼内空间，眼部药物递送一直是一个挑战。如今，研究集中在通过利用纳米颗粒作为药物跨越眼部解剖和生理屏障的运输方式来改进当前的青光眼治疗方法。这篇综述提供了关于在这个方向上取得的治疗进展的一些重要见解，重点是使用负载抗炎和神经保护剂的纳米颗粒治疗青光眼。这些新疗法的前景与当前缓解青光眼炎症的疗法相关进行了讨论，同时也对当前疗法进行了综述，并详细阐述了控制该疾病发生和发展的分子和细胞机制。
