Department of Endocrinology, National Center of Gerontology, Chinese Academy of Sciences, Beijing Hospital, Institute of Geriatric Medicine, Beijing, China.
The George Institute for Global Health at Peking University Health Science Center, Beijing, China.
J Diabetes Investig. 2022 Nov;13(11):1889-1896. doi: 10.1111/jdi.13868. Epub 2022 Jul 2.
AIMS/INTRODUCTION: To estimate the prevalence, and patient clinical and demographic profile, as well as risk factors associated with obstructive sleep apnea syndrome (OSAS) in hospitalized patients with type 2 diabetes mellitus in Beijing, China.
Hospitalized adult patients with type 2 diabetes mellitus were consecutively screened and invited for an overnight polysomnography from four hospitals in Beijing, China, from May 2016 to February 2017. We used the American Academy of Sleep Medicine 2012 polysomnography recording techniques and scoring criteria to identify the type of apnea and the severity of OSAS. The χ -test was used to evaluate differences between groups regarding the prevalence, and demographic and other clinical parameters.
A total of 735 patients were found eligible for the study, of whom 309 patients completed the overnight polysomnography. The mean age of the patients was 58.2 ± 10.9 years, and most (67.3%) were men. The prevalence of overall (apnea hypopnea index ≥5/h), moderate-to-severe (apnea hypopnea index ≥15/h) and severe (apnea hypopnea index ≥30/h) OSAS was 66.3% (95% confidence interval 60.8-71.6%), 35.6% (95% confidence interval 30.3-41.2%) and 16.5% (95% confidence interval 12.5-21.1%), respectively. Central and mixed apnea contributed 12% to all sleep-disordered breathing. With the aggravation of OSAS, the combined prevalence for central, mixed and obstructive apnea increased from 57% to 70%. We found OSAS to be associated with older age, obesity, self-reported snoring and apnea, and diabetes complications.
Guidelines on screening and treatment of OSAS among hospitalized patients with diabetes are needed to direct the routine practice for diabetes endocrinologists for optimal clinical care of such patients.
目的/引言：本研究旨在评估中国北京住院 2 型糖尿病患者中阻塞性睡眠呼吸暂停综合征（OSAS）的患病率、患者临床和人口统计学特征，以及与 OSAS 相关的危险因素。
2016 年 5 月至 2017 年 2 月，连续筛查并邀请中国北京四家医院的成年住院 2 型糖尿病患者进行夜间多导睡眠图检查。我们使用美国睡眠医学学会 2012 年多导睡眠图记录技术和评分标准来确定呼吸暂停类型和 OSAS 的严重程度。采用 χ 2 检验评估各组之间在患病率、人口统计学和其他临床参数方面的差异。
共发现 735 例符合研究条件的患者，其中 309 例完成了夜间多导睡眠图检查。患者的平均年龄为 58.2±10.9 岁，大多数（67.3%）为男性。总的（呼吸暂停低通气指数≥5/h）、中重度（呼吸暂停低通气指数≥15/h）和重度（呼吸暂停低通气指数≥30/h）OSAS 的患病率分别为 66.3%（95%置信区间 60.8-71.6%）、35.6%（95%置信区间 30.3-41.2%）和 16.5%（95%置信区间 12.5-21.1%）。中枢性和混合性呼吸暂停占所有睡眠呼吸障碍的 12%。随着 OSAS 的加重，中枢性、混合性和阻塞性呼吸暂停的联合患病率从 57%增加到 70%。我们发现 OSAS 与年龄较大、肥胖、自述打鼾和呼吸暂停以及糖尿病并发症有关。
需要针对住院糖尿病患者制定 OSAS 筛查和治疗指南，以指导糖尿病内分泌科医生的常规实践，为这些患者提供最佳临床护理。
