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24 个月的纵向血清学监测显示,玻利维亚查科地区学龄儿童中克氏锥虫媒介传播的持续存在。

Persistence of Trypanosoma cruzi vector-borne transmission among school-age children in the Bolivian Chaco documented by 24-month longitudinal serosurveillance.

机构信息

Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Firenze, Italy.

SOD Malattie Infettive e Tropicali, Azienda Ospedaliero Universitaria Careggi, Firenze, Italy.

出版信息

Trans R Soc Trop Med Hyg. 2023 Jan 3;117(1):58-60. doi: 10.1093/trstmh/trac065.

DOI:10.1093/trstmh/trac065
PMID:35779279
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9808515/
Abstract

BACKGROUND

Chagas disease represents a major public health concern in several Latin American countries, including Bolivia.

METHODS

We present a longitudinal serosurvey for Trypanosoma cruzi antibodies among a cohort of 120 school-age children from rural communities in the Bolivian Chaco at three time points between 2017 and 2019. Serum samples extracted from dry blood spots collected on filter paper were tested for T. cruzi antibodies by enzyme-linked immunosorbent assay and rapid diagnostic test.

RESULTS

T. cruzi antibodies were detected in 7/120 (5.8%), 8/120 (6.7%) and 11/120 (9.2%) samples in 2017, 2018 and 2019, respectively. An average incidence of 1.76 per 100 person-years was observed.

CONCLUSIONS

Our findings support the persistence of vector-borne T. cruzi transmission in this area, highlighting the need for strengthening multidisciplinary efforts against Chagas disease.

摘要

背景

恰加斯病是拉丁美洲多个国家(包括玻利维亚)的一个主要公共卫生关注点。

方法

我们在 2017 年至 2019 年期间的三个时间点,对玻利维亚查科地区农村社区的 120 名学龄儿童进行了纵向血清学调查,以检测克氏锥虫抗体。从滤纸采集的干血斑中提取血清样本,通过酶联免疫吸附试验和快速诊断检测来检测 T. cruzi 抗体。

结果

2017 年、2018 年和 2019 年分别有 7/120(5.8%)、8/120(6.7%)和 11/120(9.2%)的样本中检测到 T. cruzi 抗体。平均发病率为每 100 人年 1.76 例。

结论

我们的研究结果支持该地区媒介传播的 T. cruzi 持续存在,强调了需要加强多学科努力以对抗恰加斯病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/476d/9808515/01a5e92b10c8/trac065fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/476d/9808515/01a5e92b10c8/trac065fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/476d/9808515/01a5e92b10c8/trac065fig1.jpg

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J Infect Dev Ctries. 2020 Feb 29;14(2):199-206. doi: 10.3855/jidc.11127.
2
Chagas disease in the Bolivian Chaco: Persistent transmission indicated by childhood seroscreening study.玻利维亚查科的查加斯病:儿童血清筛查研究表明持续传播。
Int J Infect Dis. 2019 Sep;86:175-177. doi: 10.1016/j.ijid.2019.07.020. Epub 2019 Jul 26.
3
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Canine Trypanosoma cruzi infection in the Bolivian Chaco.玻利维亚查科的犬感染克氏锥虫。
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Comparison of Serology Performed on Dried Blood Spots and on Conventional Serum Samples.干血斑与传统血清样本血清学检测的比较
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