玻利维亚查科的查加斯病：儿童血清筛查研究表明持续传播。

Chagas disease in the Bolivian Chaco: Persistent transmission indicated by childhood seroscreening study.

机构信息

Warwick Medical School, The University of Warwick, Coventry, UK.

School of Life Sciences, The University of Warwick, Coventry, UK.

出版信息

Int J Infect Dis. 2019 Sep;86:175-177. doi: 10.1016/j.ijid.2019.07.020. Epub 2019 Jul 26.

DOI:10.1016/j.ijid.2019.07.020

PMID:31357060

Abstract

BACKGROUND

Screening for Trypanosoma cruzi infection was performed amongst children in a rural community in the Bolivian Chaco, an area known for high prevalence. The force of infection (FOI) was estimated.

METHODS

A total of 423 children attending the local school were screened using the Chagas Detect Plus (CDP) rapid test (InBios International, Inc.). CDP-positive specimens were further tested by indirect haemagglutination assay (IHA) and Wiener Recombinante v3.0 ELISA. A catalytic model was used to estimate FOI.

RESULTS

Confirmed seroprevalence was 0.22, rising steeply with age. The mean age of seropositive individuals was 13 years. The calculated specificity of the rapid test was 91.9%. The annual incidence estimated from the FOI was 0.021.

CONCLUSIONS

This study demonstrates persistent transmission and continuing high levels of T. cruzi infection in the Bolivian Chaco, and highlights the practicality of school-based screening.

摘要

背景

在玻利维亚查科的一个农村社区中，对儿童进行了克氏锥虫感染筛查，该地区的感染率很高。估计了感染力度（FOI）。

方法

共有 423 名就读于当地学校的儿童接受了 Chagas Detect Plus（CDP）快速检测（InBios International，Inc.）的筛查。CDP 阳性样本进一步通过间接血凝试验（IHA）和 Wiener Recombinante v3.0 ELISA 进行检测。使用催化模型来估计 FOI。