COVID-19 孕妇早期的脑脊液分析。
Cerebrospinal fluid analysis of pregnant women at early stages of COVID-19.
机构信息
Department of Obstetrics and Gynecology, University of Brasília, Brasília, Brazil; Postgraduate Program in Medical Sciences, University of Brasília, Brasília, Brazil.
Postgraduate Program in Medical Sciences, University of Brasília, Brasília, Brazil; Department of Pediatrics, University of Brasília, Brasília, Brazil.
出版信息
Taiwan J Obstet Gynecol. 2022 Jul;61(4):672-674. doi: 10.1016/j.tjog.2022.03.043. Epub 2022 May 23.
OBJECTIVE
To determine the presence or absence of SARS-CoV-2 in the cerebrospinal fluid of pregnant women at early stages of COVID-19.
MATERIALS AND METHODS
We conducted a prospective observational study with pregnant women undergoing cesarean section and real-time polymerase chain reaction to SARS-CoV-2 was performed in the cerebrospinal fluid in the early stages of COVID-19.
RESULTS
Fourteen pregnant women, whose COVID-19 symptoms started between four to 18 days prior to delivery, were included. Eleven of the women reported anosmia, dysgeusia, and headaches and there were two fatal cases. SARS-Cov-2 was not present in the cerebrospinal fluid of these COVID-19 patients with early neurological symptoms, even in severe cases.
CONCLUSION
Our study suggests that peripheric cell damage and parainfectious phenomena may predominate over direct central nervous system injury in the pathophysiology of COVID-19 related early neurological symptoms on pregnant women.
目的
确定 COVID-19 早期孕妇的脑脊液中是否存在 SARS-CoV-2。
材料和方法
我们进行了一项前瞻性观察研究，对行剖宫产术的孕妇进行了实时聚合酶链反应检测，以检测 COVID-19 早期的 SARS-CoV-2 在脑脊液中的存在情况。
结果
共纳入 14 例 COVID-19 症状在分娩前 4 至 18 天开始的孕妇。其中 11 例患者报告有嗅觉丧失、味觉障碍和头痛，有 2 例死亡病例。即使在严重的情况下，这些有早期神经症状的 COVID-19 患者的脑脊液中也未检测到 SARS-Cov-2。
结论
本研究表明，在 COVID-19 相关早期神经症状的病理生理学中，外周细胞损伤和副感染现象可能比直接中枢神经系统损伤更为常见。
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