Osteoporosis Research and Diagnosis Center - CEDOES, Vitoria, Brazil.
Federal University of Espirito Santo, Vitoria, Brazil.
Arch Osteoporos. 2022 Jul 2;17(1):90. doi: 10.1007/s11657-022-01127-4.
Hip fracture incidence rates in three representative geographic areas in Brazil over a period of 2 years (2010-2012) were assessed for the first time. Estimated incidence rates varied regionally, and markedly differed from those previously reported. Thus, national guidelines as well as FRAX Brazil should be revised in light of this new data.
To determine the annual incidence of hip fractures in individuals aged 50 years and over, living in 3 cities located in different regions of the country. To investigate the age, gender, and regional differences in fracture rates. Based on the obtained data, to estimate the national incidence of hip fractures resulting from osteoporosis, in order to improve prevention strategies.
Retrospective, observational study including all patients aged ≥ 50 years admitted in hospitals because of a hip fracture in three cities (Belem, Joinville, and Vitoria) from representative geographic areas in Brazil from 2010 to 2012. Data were obtained from medical records in those cities. We analyzed incidence rates (crude and age- and gender-standardized rates) for hip fractures.
There were 1025 (310 in men and 715 in women) hip fractures in the over 50-year-old merged population from the three cities. The crude incidence rate for hip fracture was 103.3/100,000 (95% confidence interval [CI = 97.0; 109.7), in men 77.4/100,000 (95% CI = 68.8; 86.0), and in women 125.2/100,000 (95% CI = 116.0; 134.4). Incidence standardized for age and gender was 105.9 cases per 100,000 persons per year (95% CI = 99.4; 112.4); 78.5 cases per 100,000 (95% CI = 69.8; 87.3) in men and 130.6 cases 100,000 in women (95% CI = 121.0, 140.2) per year. Belem, located in the equatorial region (latitude 1° 27' S), had significantly lower crude and age-adjusted incidence than Joinville (latitude 26° 18' S) and Vitoria (latitude 20° 19' S), which were no different from each other. The incidence of fractures increased exponentially with age, and women had about twice the risk of fractures than men.
Hip fracture mainly affects elderly women and presents great variability in incidence between the different regions in Brazil. The incidence of hip fractures in Brazil differed markedly from that reported previously, so that national guidelines and the FRAX model for Brazil should be revised.
确定巴西三个不同地区 50 岁及以上人群髋部骨折的年发生率，调查骨折发生率的年龄、性别和地区差异。根据获得的数据，估算骨质疏松性髋部骨折的全国发生率，以改进预防策略。
这是一项回顾性、观察性研究，纳入了 2010 年至 2012 年间巴西三个具有代表性地区（贝伦、若因维利和维多利亚）3 家医院因髋部骨折收治的所有 50 岁及以上患者。从这些城市的病历中获取数据。我们分析了髋部骨折的发生率（粗发生率和年龄及性别标准化发生率）。
在这三个城市的合并人群中，50 岁以上人群中有 1025 例（男性 310 例，女性 715 例）髋部骨折。男性髋部骨折的粗发生率为 77.4/100000（95%可信区间[CI]：68.8；86.0），女性为 125.2/100000（95%CI：116.0；134.4）。年龄和性别标准化的发生率为 105.9 例/100000 人/年（95%CI：99.4；112.4）；男性为 78.5 例/100000（95%CI：69.8；87.3），女性为 130.6 例/100000 人/年（95%CI：121.0；140.2）。位于赤道地区（南纬 1°27'）的贝伦与位于南纬 26°18'的若因维利和南纬 20°19'的维多利亚相比，粗发生率和年龄调整后发生率均显著较低，但后两者之间无差异。骨折发生率随年龄呈指数增长，女性骨折风险约为男性的 2 倍。
髋部骨折主要影响老年女性，巴西不同地区的发病率差异很大。巴西髋部骨折的发生率与之前报道的明显不同，因此应修订国家指南和巴西 FRAX 模型。
