Tyagi Ravi, Ahmed S Samaduddin, Koethe Yilun, Raskind Aleksandr, Ahmed Osman
University of Illinois College of Medicine at Chicago, Chicago, Illinois.
Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois.
Semin Intervent Radiol. 2022 Jun 30;39(2):125-129. doi: 10.1055/s-0042-1745798. eCollection 2022 Apr.
Genicular artery embolization (GAE) is a novel treatment for knee osteoarthritis (OA) with increasing interest and utilization worldwide. The genicular arteries are selectively embolized using microspheres with subsequent cessation of abnormal synovial hyperemia, a process believed to arrest the inflammatory changes and pain associated with OA. Current data indicate that GAE offers sustained, 6-month improvement in Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and visual analog scale scores in 80 to 85% of patients with mild to moderate OA. As GAE gains traction, future studies are needed to establish its safety and efficacy relative to placebo and other standard-of-care therapies while also characterizing populations for which it is most effective.
膝动脉栓塞术（GAE）是一种治疗膝关节骨关节炎（OA）的新型疗法，在全球范围内受到越来越多的关注并得到应用。使用微球选择性栓塞膝动脉，随后异常滑膜充血停止，这一过程被认为可以阻止与OA相关的炎症变化和疼痛。目前的数据表明，在80%至85%的轻至中度OA患者中，GAE可使西安大略和麦克马斯特大学骨关节炎指数（WOMAC）和视觉模拟量表评分持续改善6个月。随着GAE越来越受到关注，需要开展进一步研究以确定其相对于安慰剂和其他标准治疗方法的安全性和有效性，同时还要明确对其疗效最佳的人群特征。
