Radwaner B A, Geringer R, Goldmann A M, Schwartz M J, Kemp H G
Am J Med. 1987 May;82(5):1017-20. doi: 10.1016/0002-9343(87)90167-7.
The association of mediastinal radiation therapy and coronary artery disease has been documented over the past three decades. This report describes a case of left main coronary artery stenosis eight years after radiation therapy in a 27-year-old woman. The patient was a young woman with no risk factors for coronary artery disease who had development of new-onset angina at rest. At coronary arteriography, the patient was found to have a tight ostial left main stenosis. The association of mediastinal radiation therapy with fixed and vasospastic coronary artery disease is reviewed. With many patients treated by radiation therapy now surviving their thoracic malignancies, an enlarging young population may be susceptible to the early development of ischemic heart disease.
在过去三十年中，纵隔放射治疗与冠状动脉疾病之间的关联已有文献记载。本报告描述了一名27岁女性在放射治疗八年后发生左主干冠状动脉狭窄的病例。该患者为年轻女性，无冠状动脉疾病危险因素，却出现了新发静息性心绞痛。在冠状动脉造影检查中，发现该患者存在严重的左主干开口狭窄。本文对纵隔放射治疗与固定性和血管痉挛性冠状动脉疾病之间的关联进行了综述。随着许多接受放射治疗的患者在胸部恶性肿瘤后存活下来，越来越多的年轻人群可能易患缺血性心脏病的早期发展。
