Department of Dosimetry, National Radiation Protection Institute, Prague, Czechia.
Front Public Health. 2022 Jun 16;10:908016. doi: 10.3389/fpubh.2022.908016. eCollection 2022.
Several common pharmaceuticals such as ibuprofen, paracetamol, aspirin, oral contraceptives, drugs for the prevention of motion sickness and food supplements such as table vitamins and minerals have been studied for the purposes of retrospective dosimetry using optically stimulated luminescence (OSL). The essence is that the tablets with these drug substances contain additive crystalline materials which, after irradiation and stimulation, may exhibit luminescence. For most of the pharmaceuticals and food supplements, a radiation-induced dose-dependent OSL signal was detected. Subsequently, basic dosimetric characteristics of the materials were studied, specifically sensitivity changes during repeated OSL readings, dose response, zero-dose, minimum detectable dose (MDD) and fading. The most radiation sensitive materials were food supplements with Mg providing zero-dose and MDD values at the level of several mGy. For Mg supplements, considerable sensitivity changes in OSL signal were observed. Despite this, they could be corrected using a Single-Aliquot Regenerative-dose (SAR) protocol. The OSL signals of the other materials were relatively weak but they were well reproducible and exhibited linear dose response. The MDD values were variable among the materials and ranged from 0.1 to several Gy. However, for some of the pharmaceuticals, a very high and variable zero-dose of more than 3 Gy was observed that would rule out the possibility of dose reconstruction for triage purposes. The OSL signal exhibited a significant fading rate for most of the materials. The measurements for dose reconstruction should be performed as soon as possible after irradiation, i.e. within a maximum of a few days.
几种常见的药物，如布洛芬、对乙酰氨基酚、阿司匹林、口服避孕药、预防晕动病的药物和膳食补充剂，如片剂维生素和矿物质，已经被研究用于使用光激励发光（OSL）进行回顾性剂量测定。本质上是这些含有药物物质的片剂含有添加剂结晶材料，这些材料在辐照和刺激后可能会发出发光。对于大多数药物和膳食补充剂，检测到与辐射剂量相关的 OSL 信号。随后，研究了这些材料的基本剂量学特性，特别是在重复 OSL 读数过程中的灵敏度变化、剂量响应、零剂量、最小可检测剂量（MDD）和衰退。最敏感的材料是含有 Mg 的膳食补充剂，其零剂量和 MDD 值处于几个 mGy 的水平。对于 Mg 补充剂，观察到 OSL 信号的相当大的灵敏度变化。尽管如此，它们可以使用单一样本再生剂量（SAR）协议进行校正。其他材料的 OSL 信号相对较弱，但具有良好的重现性，并且表现出线性剂量响应。MDD 值在材料之间是可变的，范围从 0.1 到几 Gy。然而，对于一些药物，观察到非常高且可变的零剂量超过 3 Gy，这将排除用于分类目的的剂量重建的可能性。大多数材料的 OSL 信号表现出显著的衰退率。剂量重建的测量应在辐照后尽快进行，即最长不超过几天。
