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单细胞组学时代胶质母细胞瘤肿瘤微环境中的髓系细胞分类和治疗机会。

Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era.

机构信息

Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Lou and Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

出版信息

Front Immunol. 2022 Jun 16;13:907605. doi: 10.3389/fimmu.2022.907605. eCollection 2022.

DOI:10.3389/fimmu.2022.907605
PMID:35784281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9244707/
Abstract

The glioma tumor microenvironment (TME) is complex and heterogeneous, and multiple emerging and current technologies are being utilized for an improved comprehension and understanding of these tumors. Single cell analysis techniques such as single cell genomic and transcriptomic sequencing analysis are on the rise and play an important role in elucidating the glioma TME. These large datasets will prove useful for patient tumor characterization, including immune configuration that will ultimately influence therapeutic choices and especially immune therapies. In this review we discuss the advantages and drawbacks of these techniques while debating their role in the domain of glioma-infiltrating myeloid cells characterization and function.

摘要

脑胶质瘤肿瘤微环境（TME）复杂且异质，目前有多种新兴技术和现有技术被用于更好地理解和研究这些肿瘤。单细胞分析技术，如单细胞基因组和转录组测序分析，正在兴起，并在阐明脑胶质瘤 TME 方面发挥着重要作用。这些大型数据集将有助于对患者肿瘤进行特征分析，包括免疫组成，这将最终影响治疗选择，尤其是免疫治疗。在这篇综述中，我们讨论了这些技术的优缺点，并探讨了它们在脑胶质瘤浸润髓样细胞特征和功能研究领域的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7528/9244707/da7b2363fc5e/fimmu-13-907605-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7528/9244707/da7b2363fc5e/fimmu-13-907605-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7528/9244707/da7b2363fc5e/fimmu-13-907605-g001.jpg

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T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10.
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