Department of Hematology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Front Immunol. 2022 Jun 16;13:890059. doi: 10.3389/fimmu.2022.890059. eCollection 2022.
Primary cardiac lymphoma (PCL) is a rare disease, the definite diagnosis of which is sometimes difficult and mainly relies on endomyocardial biopsy. Primary cardiac T-cell lymphoma (PCTL) is an extremely rare sub-type of PCL. Here, we report on a 47-year-old female with PCTL who presented with fever, syncope, palpitations, and a third-degree atrioventricular block (AVB) on electrocardiogram. Chemotherapy was administered with two courses of methotrexate, cyclophosphamide, liposomal doxorubicin, vincristine, and dexamethasone (MTX-CHOP). As the tumor vanished, AVB changed from third degree to second degree and finally to sinus rhythm. In conclusion, endomyocardial biopsy is valuable in the diagnosis of primary cardiac lymphoma. It is worth noting that alterations in the electrocardiogram may indicate an attack on the heart by PCTL.
原发性心脏淋巴瘤（PCL）是一种罕见的疾病，其明确诊断有时较为困难，主要依赖于心内膜心肌活检。原发性心脏 T 细胞淋巴瘤（PCTL）是 PCL 极罕见的亚型。在这里，我们报告了一例 47 岁女性 PCTL 患者，其表现为发热、晕厥、心悸和心电图三度房室传导阻滞（AVB）。该患者接受了两个疗程的甲氨蝶呤、环磷酰胺、脂质体多柔比星、长春新碱和地塞米松（MTX-CHOP）化疗。随着肿瘤的消失，AVB 从三度变为二度，最终变为窦性节律。总之，心内膜心肌活检对原发性心脏淋巴瘤的诊断具有重要价值。值得注意的是，心电图的改变可能提示 PCTL 对心脏的侵袭。
