Neuroscience Institute, NYU Langone Health, New York, NY 10016, USA.
School of Life Sciences, Arizona State University, Tempe, AZ 85281, USA.
Cell Rep Methods. 2022 Jun 9;2(6):100233. doi: 10.1016/j.crmeth.2022.100233. eCollection 2022 Jun 20.
Perceptual similarities between a specific stimulus and other stimuli of the same modality provide valuable information about the structure and geometry of sensory spaces. While typically assessed in human behavioral experiments, perceptual similarities-or distances-are rarely measured in other species. However, understanding the neural computations responsible for sensory representations requires the monitoring and often manipulation of neural activity, which is more readily achieved in non-human experimental models. Here, we develop a behavioral paradigm that enables the quantification of perceptual similarity between sensory stimuli using mouse olfaction as a model system.
特定刺激与同一模态的其他刺激之间的感知相似性为感知空间的结构和几何形状提供了有价值的信息。虽然通常在人类行为实验中进行评估，但在其他物种中很少测量感知相似性或距离。然而，要理解负责感觉表示的神经计算，需要监测和经常操纵神经活动，这在非人类实验模型中更容易实现。在这里，我们开发了一种行为范式，该范式使用小鼠嗅觉作为模型系统，能够量化感觉刺激之间的感知相似性。
