Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, 1991953381, Iran.
Research and Development Unit, NIAK Pharmaceutical Company, Gorgan, Iran.
Endocr Metab Immune Disord Drug Targets. 2023;23(1):46-62. doi: 10.2174/1871530322666220630091859.
Obesity and dyslipidemia are common disorders universally. According to the acquired outcomes of recent studies, dietary supplementations which have great content of phenolic compounds exert protective effects against obesity and dyslipidemia. Grape [Vitis vinifera] seeds are considered attractive sources of phenolic compounds with anti-oxidative stress and anti-inflammatory effects. There are also various experimental studies describing hepatoprotective, neuroprotective, anti-aging, cardioprotective, and anti-carcinogenic effects of polyphenols isolated from grape seed, highlighting the therapeutic and biological aspects of proanthocyanidins. The present review article first discusses pharmacological, botanical, toxicological, and phytochemical characteristics of Vitis vinifera seeds and afterward designates the protective properties which are attributed to the intake of grape seeds in obesity and hyperlipidemia. Overall valuable and updated findings of this study display that polyphenol of grape seeds has meaningful impacts on the regulation of lipid profile levels and management of obesity.
肥胖和血脂异常是普遍存在的疾病。根据最近研究的结果，含有大量酚类化合物的膳食补充剂对肥胖和血脂异常有保护作用。葡萄(Vitis vinifera)种子被认为是具有抗氧化应激和抗炎作用的酚类化合物的有吸引力的来源。还有许多实验研究描述了从葡萄籽中分离出的多酚的保肝、神经保护、抗衰老、心脏保护和抗癌作用，强调了原花青素的治疗和生物学方面。本文综述首先讨论了葡萄(Vitis vinifera)种子的药理学、植物学、毒理学和植物化学特性，然后指出了摄入葡萄籽对肥胖和高脂血症的保护特性。这项研究的总体有价值和最新的发现表明，葡萄种子的多酚对调节血脂水平和肥胖症的管理有重要影响。
