Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Nutr Neurosci. 2023 May;26(5):369-383. doi: 10.1080/1028415X.2022.2051954. Epub 2022 Mar 28.
Common neurological disorders, including neurodegenerative diseases, stroke, epilepsy, autism and psychiatric disorders, affect many people worldwide and threaten their lives and health by inducing movement disorders, behavioral disorders, or a combination of both. Oxidative stress and neuroinflammation play a central role in neuronal damage and neurological diseases induction and progression. In addition, protein homeostasis (proteostasis) impairment occurs in many neurodegenerative diseases, which plays a critical role in the progression of the pathology. Grape seed contains several flavonoids and non-flavonoids and exerts potent antioxidant and anti-inflammatory effects. In addition, polyphenols and flavanols can maintain cellular proteostasis. Since impaired proteostasis is closely involved in all amyloid diseases, particularly neurodegenerative diseases, grape seeds extract can be a valuable therapeutic agent. Therefore, this review discusses the protective and therapeutic mechanisms of grape seed against neurological disorders and, in the end, links GSE to microRNAs as future therapeutic developments.
常见的神经紊乱，包括神经退行性疾病、中风、癫痫、自闭症和精神疾病，影响着全球许多人的生活和健康，引发运动障碍、行为障碍，或两者兼而有之。氧化应激和神经炎症在神经元损伤和神经紊乱的诱导和进展中起着核心作用。此外，许多神经退行性疾病中出现蛋白质稳态（蛋白稳态）损伤，这在病理进展中起着关键作用。葡萄籽含有几种类黄酮和非类黄酮，具有强大的抗氧化和抗炎作用。此外，多酚和黄烷醇可以维持细胞内的蛋白稳态。由于蛋白稳态受损与所有淀粉样蛋白疾病，特别是神经退行性疾病密切相关，因此葡萄籽提取物可以作为一种有价值的治疗药物。因此，本综述讨论了葡萄籽对神经紊乱的保护和治疗机制，并最终将 GSE 与 microRNAs 联系起来，作为未来的治疗发展方向。
