Center for AIE Research, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
J Am Chem Soc. 2022 Jul 20;144(28):12825-12833. doi: 10.1021/jacs.2c03895. Epub 2022 Jul 5.
The construction of supramolecular coordination complexes (SCCs) featuring prominent cancer theranostic functions is an appealing yet significantly challenging task. In this study, we rationally designed and facilely constructed a prism-like metallacage C-DTTP with efficient fluorescence emission in the second near-infrared (NIR-II) region through the assembly of an aggregation-induced emission-active four-arm ligand with 90° Pt acceptors Pt(PEt)(OTf). C-DTTP held the longest maximum emission wavelength (1005 nm) compared with those previously reported SCCs up to now and exhibited both a high photothermal conversion efficiency (39.3%) and significantly superior reactive oxygen species generation behavior to the precursor ligand. In vitro and in vivo assessments demonstrated that the metallacage-loaded nanoparticles with excellent biocompatibility and stability were capable of simultaneously affording precise tumor diagnosis and complete tumor elimination by means of NIR-II fluorescence/photothermal dual imaging-guided photodynamic/photothermal synergistic therapy.
构建具有显著癌症治疗功能的超分子配位化合物（SCCs）是一项吸引人但极具挑战性的任务。在本研究中，我们通过将具有 90°Pt 受体 Pt(PEt)(OTf)的聚集诱导发射活性四臂配体组装，合理设计并简便构建了具有高效荧光发射的棱柱形金属笼 C-DTTP。与迄今为止报道的 SCCs 相比，C-DTTP 具有最长的最大发射波长（1005nm），并且表现出高的光热转换效率（39.3%）和明显优于前体配体的活性氧生成行为。体外和体内评估表明，负载金属笼的纳米粒子具有优异的生物相容性和稳定性，能够通过近红外二区荧光/光热双模态成像引导的光动力/光热协同治疗，实现精确的肿瘤诊断和完全肿瘤消除。
