C R Biol. 2021 Dec 20;344(4):409-420. doi: 10.5802/crbiol.71.
Proton minibeam radiation therapy (pMBRT) is a novel cancer therapy approach based on a high spatial dose modulation. pMBRT activates distinct radiobiological mechanisms and it has been shown to lead in small animal experiments to a significant increase in normal tissue dose tolerances while maintaining or enhancing tumor control effectiveness as compared with conventional radiotherapy. Although recently proposed, the biological observations collected thus far challenge the classical paradigm in RT and encourage the preparation of phase I clinical trials.
质子微束放射治疗（pMBRT）是一种基于高空间剂量调制的新型癌症治疗方法。pMBRT 激活了独特的放射生物学机制，并且在小动物实验中已经表明，与传统放射治疗相比，它可以显著提高正常组织剂量耐受性，同时保持或提高肿瘤控制效果。尽管最近才提出，但迄今为止收集的生物学观察结果挑战了 RT 的经典范式，并鼓励进行 I 期临床试验的准备。
