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采用高效液相色谱法分析尿液样本对吡嗪酰胺代谢情况的研究。

Study of the metabolism of pyrazinamide using a high-performance liquid chromatographic analysis of urine samples.

作者信息

Yamamoto T, Moriwaki Y, Takahashi S, Hada T, Higashino K

出版信息

Anal Biochem. 1987 Feb 1;160(2):346-9. doi: 10.1016/0003-2697(87)90058-3.

DOI:10.1016/0003-2697(87)90058-3
PMID:3578761
Abstract

A reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of pyrazinamide and its metabolites in urine. Study of the metabolism of pyrazinamide by this method demonstrated that 5-hydroxypyrazinamide excretion was compatible with pyrazinoic acid excretion and allopurinol decreased in vivo conversion of pyrazinamide to 5-hydroxypyrazinamide and blocked that of pyrazinoic acid to 5-hydroxypyrazinoic acid.

摘要

建立了一种反相高效液相色谱法，用于同时测定尿液中吡嗪酰胺及其代谢物。用该方法对吡嗪酰胺代谢进行的研究表明，5-羟基吡嗪酰胺的排泄与吡嗪酸的排泄情况相符，别嘌呤醇可降低吡嗪酰胺在体内向5-羟基吡嗪酰胺的转化，并阻断吡嗪酸向5-羟基吡嗪酸的转化。

相似文献

1
Study of the metabolism of pyrazinamide using a high-performance liquid chromatographic analysis of urine samples.采用高效液相色谱法分析尿液样本对吡嗪酰胺代谢情况的研究。
Anal Biochem. 1987 Feb 1;160(2):346-9. doi: 10.1016/0003-2697(87)90058-3.
2
A case of xanthinuria: a study on the metabolism of pyrazinamide and allopurinol.一例黄嘌呤尿症：关于吡嗪酰胺和别嘌醇代谢的研究。
Jpn J Med. 1991 Sep-Oct;30(5):430-4. doi: 10.2169/internalmedicine1962.30.430.
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Study of urinary pyrazinamide metabolites and their action on the renal excretion of xanthine and hypoxanthine in a xanthinuric patient.黄嘌呤尿症患者尿液中吡嗪酰胺代谢产物及其对黄嘌呤和次黄嘌呤肾排泄作用的研究。
Biomedicine. 1978 May;28(2):129-33.
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Metabolism of pyrazinamide and allopurinol in hereditary xanthine oxidase deficiency.遗传性黄嘌呤氧化酶缺乏症中吡嗪酰胺和别嘌醇的代谢
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[Microdetermination of pyrazinamide and its metabolites (pyrazinoic acid, 5-hydroxypyrazinoic acid, 5-hydroxypyrazinamide and pyrazinuric acid) in plasma and urine with liquid chromatography].[用液相色谱法微量测定血浆和尿液中的吡嗪酰胺及其代谢产物（吡嗪酸、5-羟基吡嗪酸、5-羟基吡嗪酰胺和吡嗪尿酸）]
J Chromatogr. 1987 Nov 27;422:217-25.
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In vitro conversion of pyrazinamide into 5-hydroxypyrazinamide and that of pyrazinoic acid into 5-hydroxypyrazinoic acid by xanthine oxidase from human liver.人肝脏中的黄嘌呤氧化酶将吡嗪酰胺体外转化为5-羟基吡嗪酰胺以及将吡嗪酸体外转化为5-羟基吡嗪酸。
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Effect of BOF-4272 on the oxidation of allopurinol and pyrazinamide in vivo. Is xanthine dehydrogenase or aldehyde oxidase more important in oxidizing both allopurinol and pyrazinamide?
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Int J Clin Pharmacol Ther. 1995 Jun;33(6):360-5.

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