Yamamoto T, Moriwaki Y, Takahashi S, Suda M, Higashino K
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
Int J Clin Pharmacol Ther. 1995 Jun;33(6):360-5.
We investigated the effect of xylitol on the plasma concentration and the urinary excretion of purine bases, 5-hydroxypyrazinamide and 5-hydroxypyrazinoic acid in subjects who had ingested pyrazinamide (60 mg/kg weight). One liter of 10% xylitol was infused intravenously over 2 hours to 5 subjects to whom pyrazinamide had been administered 10 hours before. Xylitol increased the plasma concentration of uric acid, hypoxanthine and xanthine, the urinary excretion of hypoxanthine and a ratio of lactic acid/pyruvic acid in blood, while it decreased the plasma concentration and the urinary excretion of inorganic phosphate, 5-hydroxypyrazinamide and 5-hydroxypyrazinoic acid. These results suggested that in addition to an increase in purine degradation by xylitol, xylitol-induced increase in the cytosolic NADH inhibited xanthine dehydrogenase activity in the liver and the small intestine.
我们研究了木糖醇对摄入吡嗪酰胺（60毫克/千克体重）的受试者血浆中嘌呤碱、5-羟基吡嗪酰胺和5-羟基吡嗪酸浓度以及尿排泄的影响。在5名10小时前已服用吡嗪酰胺的受试者中，在2小时内静脉输注1升10%的木糖醇。木糖醇增加了尿酸、次黄嘌呤和黄嘌呤的血浆浓度、次黄嘌呤的尿排泄量以及血液中乳酸/丙酮酸的比率，同时降低了无机磷酸盐、5-羟基吡嗪酰胺和5-羟基吡嗪酸的血浆浓度及尿排泄量。这些结果表明，除了木糖醇增加嘌呤降解外，木糖醇诱导的胞质NADH增加抑制了肝脏和小肠中的黄嘌呤脱氢酶活性。
