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内分泌干扰物与女性生育能力:农药和增塑剂影响的综述

Endocrine disruptors and female fertility: a review of pesticide and plasticizer effects.

作者信息

Vessa Blake, Perlman Barry, McGovern Peter G, Morelli Sara S

机构信息

Department of Obstetrics, Gynecology and Reproductive Health, Rutgers New Jersey Medical School, Newark, New Jersey.

出版信息

F S Rep. 2022 Apr 15;3(2):86-90. doi: 10.1016/j.xfre.2022.04.003. eCollection 2022 Jun.

Abstract

An ongoing interest in environmental exposures and female fertility has led to an increasing number of studies focusing on endocrine-disrupting chemicals (EDCs). Both natural and synthetic compounds have the ability to impact reproductive health by altering the structure and/or function of genes and proteins that facilitate normal ovarian and endometrial functions. This mini-review aims to summarize the effects of some of the most common EDCs on female fertility, including the effects of pesticides and plasticizer alternatives (phthalates, bisphenol A), based on available data in human studies. A literature search was performed using the key words "pesticides, fertility, reproduction, plasticizers, bisphenol A, phthalate, miscarriage, and in vitro fertilization." The data supporting EDCs' role in female infertility remain limited, but existing evidence suggests that exposure may have an adverse impact. Accumulating evidence in animal studies provides important insights into the mechanisms underlying EDC effects. As dose-response dynamics are better elucidated, understanding the effects of EDCs on female fertility will help in the development of guidelines for both industry and individuals.

摘要

对环境暴露与女性生育能力的持续关注,促使越来越多的研究聚焦于内分泌干扰化学物质(EDCs)。天然和合成化合物都有能力通过改变促进正常卵巢和子宫内膜功能的基因和蛋白质的结构和/或功能来影响生殖健康。本综述旨在根据人体研究的现有数据,总结一些最常见的内分泌干扰化学物质对女性生育能力的影响,包括农药和增塑剂替代品(邻苯二甲酸盐、双酚A)的影响。使用关键词“农药、生育能力、生殖、增塑剂、双酚A、邻苯二甲酸盐、流产和体外受精”进行了文献检索。支持内分泌干扰化学物质在女性不孕中作用的数据仍然有限,但现有证据表明暴露可能产生不利影响。动物研究中不断积累的证据为内分泌干扰化学物质作用的潜在机制提供了重要见解。随着剂量反应动态得到更好的阐明,了解内分泌干扰化学物质对女性生育能力的影响将有助于制定针对行业和个人的指导方针。

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