Macut D, Opalić M, Popović B, Ognjanović S, Bjekić-Macut J, Livadas S, Petrović T, Hrnčić D, Stanojlović O, Milutinović D Vojnović, Micić D, Mastorakos G
University of Belgrade, Faculty of Medicine - Clinic for Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Centre of Serbia, Belgrade, Serbia.
Clinic for Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Centre of Serbia, Belgrade, Serbia.
Acta Endocrinol (Buchar). 2023 Jan-Mar;19(1):81-86. doi: 10.4183/aeb.2023.81. Epub 2023 Aug 14.
Endocrine disruptors (EDs) are considered to have an impact on the function of reproductive axis at different levels as well on reproductive organs in both sexes. Complexity of female reproductive system influenced with various stressors including EDs lead to morphological and functional alterations. This is resulting in modulation of neuroendocrine regulation with consequent developmental irregularities and derangements, causative infertility, endometriosis as well as premature ovarian insufficiency or polycystic ovary syndrome. A number of experimental clues was obtained on female animal models using various EDs such as synthetic estrogens and phytoestrogens, neurotransmitters, pesticides or various chemicals. These substances lead towards consequent derangement of the neuroendocrine control of reproduction from early phases of reproductive development towards different phases of adult reproductive period. This text will address some novel insights into the effects of EDs on neuroendocrine regulation of gonadal axis, effects on ovaries as well on endometrium during implantation period.
内分泌干扰物（EDs）被认为会在不同水平上影响生殖轴的功能，以及两性的生殖器官。包括内分泌干扰物在内的各种应激源对女性生殖系统的复杂性产生影响，导致形态和功能改变。这会引起神经内分泌调节的变化，进而导致发育异常和紊乱、导致不孕、子宫内膜异位症以及卵巢早衰或多囊卵巢综合征。使用各种内分泌干扰物，如合成雌激素和植物雌激素、神经递质、农药或各种化学物质，在雌性动物模型上获得了许多实验线索。这些物质会导致从生殖发育早期到成年生殖期不同阶段的生殖神经内分泌控制出现紊乱。本文将阐述一些关于内分泌干扰物对性腺轴神经内分泌调节的影响、对卵巢以及植入期子宫内膜影响的新见解。
