极早产儿早期脑氧饱和度与脑损伤的关系。
Association of early cerebral oxygen saturation and brain injury in extremely preterm infants.
机构信息
Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
出版信息
J Perinatol. 2022 Oct;42(10):1385-1391. doi: 10.1038/s41372-022-01447-w. Epub 2022 Jul 5.
Abstract
OBJECTIVE
To assess the association between cerebral saturation (crSO) using Near-Infrared Spectroscopy (NIRS) and brain injury in extremely preterm infants.
STUDY DESIGN
This retrospective study includes 62 infants (<28 weeks gestation) who underwent continuous NIRS monitoring in the first 5 days after birth. Median crSO were compared in 12 h increments between infants with and without germinal matrix/intraventricular hemorrhage (GM/IVH). crSO was also compared by IVH severity, onset, and by grade of injury on term equivalent MRI.
RESULTS
After 48 h of life (HOL), infants with GM/IVH had significantly lower crSO than those without GM/IVH in analysis adjusted for potential confounding e.g., at 49-60 HOL (69.5 (66.2, 72.8) vs. 74.7 (71.8, 77.6), p = 0.023). There were no significant differences in crSO by IVH subcategory or injury severity on MRI.
CONCLUSION
Clinical use of NIRS has the potential to identify crSO patterns associated with development of GM/IVH.
摘要
目的
评估近红外光谱（NIRS）脑饱和度（crSO）与极早产儿脑损伤的关系。
研究设计
本回顾性研究纳入了 62 名（<28 周胎龄）出生后 5 天内接受连续 NIRS 监测的婴儿。在伴有和不伴有脑室内出血（GM/IVH）的婴儿中，比较 crSO 在 12 小时增量之间的中位数。还按 IVH 严重程度、发病时间和 MRI 上损伤的严重程度比较 crSO。
结果
在 48 小时生命后（HOL），在调整了潜在混杂因素（例如，在 49-60 HOL）后，伴有 GM/IVH 的婴儿 crSO 明显低于无 GM/IVH 的婴儿，分别为 69.5（66.2，72.8）和 74.7（71.8，77.6），p=0.023）。在 IVH 亚组或 MRI 上的损伤严重程度方面，crSO 没有显著差异。
结论
NIRS 的临床应用有可能识别与 GM/IVH 发展相关的 crSO 模式。
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