IFNα 通过重编代谢交叉对话增强免疫检查点阻断。
IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk.
机构信息
Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland.
Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
出版信息
Cancer Discov. 2022 Jul 6;12(7):1615-1616. doi: 10.1158/2159-8290.CD-22-0472.
PMID:35791695
Abstract
In this issue, Hu and colleagues unveil that IFNα administration combined with anti-PD-1 therapy can potentiate murine and human CD8+ T-cell antitumor response in hepatocellular carcinoma, highlighting a novel therapeutic strategy for hepatocellular carcinoma. See related article by Hu et al., p. 1718 (6) .
摘要
本期，胡教授及其同事揭示了 IFNα 联合抗 PD-1 治疗可以增强肝癌模型中 CD8+T 细胞的抗肿瘤反应，为肝癌治疗提供了新的策略。（6）
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