Department of Internal Medicine, University of Veterinary Medicine, Budapest, Hungary.
Department of Obstetrics and Food Animal Medicine Clinic, University of Veterinary Medicine, Budapest, Hungary.
Vet Clin Pathol. 2022 Dec;51(4):585-590. doi: 10.1111/vcp.13149. Epub 2022 Jul 6.
Albuminuria is an important marker of renal damage and can precede proteinuria; thus, it can be a useful analyte in the early diagnosis of kidney diseases. Albuminuria has also been found in dogs with hypertension, inflammatory, infectious, and neoplastic diseases.
The aim of this study was to establish a reference interval (RI) for albuminuria in dogs.
One hundred sixty-four clinically healthy dogs were enrolled in the study. Urinary albumin was determined by the immunoturbidimetric method, and albumin excretion was expressed as the urinary albumin-to-creatinine (UAC) ratio. The RI for UAC was established.
After exclusions, 124 dogs from 32 breeds remained. The median UAC of the study population was 3.0 mg/g (range: 0-48). The RI was defined as 0-19 mg/g (with a 90% CI for the upper limit of 13-28 mg/g). No significant difference was found between male and female dogs or between different age and body weight groups. The results of Sighthounds (n = 30) and Beagle dogs (n = 23) did not differ from the other breeds.
The canine RI of UAC is similar but somewhat narrower than the human RI.
白蛋白尿是肾脏损伤的一个重要标志物，可先于蛋白尿出现；因此，它可以作为肾脏疾病早期诊断的一个有用指标。在患有高血压、炎症、感染和肿瘤性疾病的犬中也发现了白蛋白尿。
本研究旨在建立犬白蛋白尿的参考区间（RI）。
本研究纳入了 164 只临床健康的犬。采用免疫比浊法测定尿白蛋白，以尿白蛋白与肌酐（UAC）的比值表示白蛋白排泄量。建立 UAC 的 RI。
排除后，32 个品种的 124 只犬被纳入研究。研究人群的 UAC 中位数为 3.0mg/g（范围：0-48）。RI 定义为 0-19mg/g（90%置信区间上限为 13-28mg/g）。雄性和雌性犬之间以及不同年龄和体重组之间无显著差异。灵缇犬（n=30）和比格犬（n=23）的结果与其他品种无差异。
犬的 UAC 的 RI 与人类 RI 相似，但略窄。
