Fernandez-Guerrero M, Rouse M S, Henry N K, Geraci J E, Wilson W R
Antimicrob Agents Chemother. 1987 Mar;31(3):430-3. doi: 10.1128/AAC.31.3.430.
In vitro activity of ciprofloxacin against 27 strains of enterococci was inoculum dependent. Using inocula of 10(5) to 10(6) or 10(7) to 10(8) CFU of enterococci per ml, the MICs for 50 and 90% of strains tested increased from 1 to greater than or equal to 128 micrograms of ciprofloxacin per ml with the higher inoculum compared with the lower inoculum. The MBC for 50% of strains tested increased from 2 to greater than 128 micrograms/ml and the MBC for 90% of strains tested increased from 8 to greater than 128 micrograms of ciprofloxacin per ml with the lower and higher inocula, respectively. The combination of penicillin-gentamicin was more effective in vitro than the combination of ciprofloxacin-gentamicin against the low or high inoculum of enterococci. Using two strains of enterococci, we studied the efficacy of ciprofloxacin in the treatment of enterococcal experimental endocarditis in rabbits. Ciprofloxacin used alone or combined with gentamicin was significantly less effective (P less than 0.01) than procaine penicillin alone or procaine penicillin combined with gentamicin for the treatment of enterococcal experimental endocarditis. The combination of ciprofloxacin-procaine penicillin was not a more effective therapy than procaine penicillin alone.
环丙沙星对27株肠球菌的体外活性与接种量有关。每毫升接种10⁵至10⁶或10⁷至10⁸CFU的肠球菌，与较低接种量相比，较高接种量时50%和90%受试菌株的最低抑菌浓度（MIC）从每毫升1微克环丙沙星增加至大于或等于128微克。50%受试菌株的最低杀菌浓度（MBC）从每毫升2微克增加至大于128微克，90%受试菌株的MBC分别从每毫升8微克增加至大于128微克环丙沙星，较低和较高接种量时情况各异。青霉素-庆大霉素联合用药在体外对低接种量或高接种量肠球菌的效果比环丙沙星-庆大霉素联合用药更好。我们使用两株肠球菌研究了环丙沙星治疗兔实验性肠球菌心内膜炎的疗效。单独使用环丙沙星或与庆大霉素联合使用，在治疗兔实验性肠球菌心内膜炎方面，明显不如单独使用普鲁卡因青霉素或普鲁卡因青霉素与庆大霉素联合使用有效（P<0.01）。环丙沙星-普鲁卡因青霉素联合用药并不比单独使用普鲁卡因青霉素疗效更好。
