COVID-19 累及中枢神经系统导致儿童出现耐药性急性局灶性运动性癫痫发作。
Medication-resistant acute focal motor seizures in a child with COVID-19 affecting the CNS.
机构信息
Department of Pediatric Neurology, Golestan Medical, Educational, and Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
出版信息
Epileptic Disord. 2022 Oct 1;24(5):941-946. doi: 10.1684/epd.2022.1461.
Abstract
A perfectly healthy preschool girl presented with acute repetitive focal aware motor seizures, while her brain MRI showed a lesion in the left posterior cortex. After a number of investigations, her cerebrospinal fluid PCR was positive for SARS-CoV-2. Despite receiving at least four anti-seizure medications at appropriate dosages, the seizures continued, and just after administering intravenous immunoglobulin, her seizures stopped. This dramatic response to intravenous immunoglobulin may indicate a hypothetical inflammatory process in the patient's cortex caused by COVID-19.
摘要
一位完全健康的学龄前女孩出现急性复发性局灶性意识运动性癫痫发作，其脑部 MRI 显示左后侧皮质有一处病变。经过多项检查，她的脑脊液 PCR 对 SARS-CoV-2 呈阳性。尽管她接受了至少四种适当剂量的抗癫痫药物治疗，但癫痫仍持续发作，就在静脉注射免疫球蛋白后，她的癫痫发作停止了。静脉注射免疫球蛋白的这种显著反应可能表明 COVID-19 引起患者皮质的假设炎症过程。
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