饮食和喂养方式调节回肠微生物组和转录组的昼夜动态。
Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome.
机构信息
Division of Gastroenterology, University of California, San Diego, 9500 Gilman Drive, MC 0983, La Jolla, CA, USA; Department of Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0983, La Jolla, CA, USA.
Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA; Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA; Center for Microbiome Innovation, University of California, San Diego, 9500 Gilman Drive, MC 0983, La Jolla, CA, USA.
出版信息
Cell Rep. 2022 Jul 5;40(1):111008. doi: 10.1016/j.celrep.2022.111008.
Compositional oscillations of the gut microbiome are essential for normal peripheral circadian rhythms, both of which are disrupted in diet-induced obesity (DIO). Although time-restricted feeding (TRF) maintains circadian synchrony and protects against DIO, its impact on the dynamics of the cecal gut microbiome is modest. Thus, other regions of the gut, particularly the ileum, the nexus for incretin and bile acid signaling, may play an important role in entraining peripheral circadian rhythms. We demonstrate the effect of diet and feeding rhythms on the ileal microbiome composition and transcriptome in mice. The dynamic rhythms of ileal microbiome composition and transcriptome are dampened in DIO. TRF partially restores diurnal rhythms of the ileal microbiome and transcriptome, increases GLP-1 release, and alters the ileal bile acid pool and farnesoid X receptor (FXR) signaling, which could explain how TRF exerts its metabolic benefits. Finally, we provide a web resource for exploration of ileal microbiome and transcriptome circadian data.
肠道微生物组的组成性振荡对于正常的外周昼夜节律至关重要，而饮食诱导的肥胖（DIO）会破坏这两者。尽管限时喂养（TRF）能保持昼夜节律同步并预防 DIO，但它对盲肠肠道微生物组动态的影响是适度的。因此，肠道的其他区域，特别是回肠，作为肠促胰岛素和胆汁酸信号的交汇点，可能在使外周昼夜节律同步方面发挥重要作用。我们证明了饮食和喂养节律对小鼠回肠微生物组组成和转录组的影响。在 DIO 中，回肠微生物组组成和转录组的动态节律减弱。TRF 部分恢复了回肠微生物组和转录组的昼夜节律，增加了 GLP-1 的释放，并改变了回肠胆汁酸池和法尼醇 X 受体（FXR）信号，这可以解释 TRF 如何发挥其代谢益处。最后，我们提供了一个网络资源，用于探索回肠微生物组和转录组的昼夜节律数据。
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