Tenenbein M, Cohen S, Sitar D S
Arch Intern Med. 1987 May;147(5):905-7.
Whole bowel irrigation, routinely used before colonoscopy, is evaluated as a potential gastrointestinal decontamination procedure for acute drug overdose. Nine adult volunteers, who served as their own controls, each ingested 5.0 g of ampicillin trihydrate on two occasions, one week apart. Whole bowel irrigation with polyethylene glycol electrolyte lavage solution was performed one hour after one ingestion. Serial serum ampicillin levels, electrolytes, osmolalities, body weights, and hematocrits were obtained. The areas under the concentration vs time curves for ampicillin were computed for both groups, and their means were compared. Mean duration of the procedure was 234 minutes and mean volume of infused polyethylene glycol electrolyte lavage solution was 7.7 L. Whole bowel irrigation produced a 67% decrease in ampicillin absorption and there were no significant changes in body weight, hematocrit, serum electrolytes, or osmolality. We conclude that whole bowel irrigation is an effective and safe gastrointestinal decontamination procedure for acute drug ingestion.
全肠道灌洗，通常在结肠镜检查前使用，现被评估为一种针对急性药物过量的潜在胃肠道去污程序。九名成年志愿者，以自身作为对照，每人分两次摄入5.0克三水合氨苄西林，两次摄入间隔一周。在一次摄入后一小时，用聚乙二醇电解质灌洗液进行全肠道灌洗。获取了连续的血清氨苄西林水平、电解质、渗透压、体重和血细胞比容。计算了两组氨苄西林浓度-时间曲线下的面积，并比较了它们的平均值。该程序的平均持续时间为234分钟，输注的聚乙二醇电解质灌洗液平均体积为7.7升。全肠道灌洗使氨苄西林吸收减少了67%，体重、血细胞比容、血清电解质或渗透压均无显著变化。我们得出结论，全肠道灌洗是一种用于急性药物摄入的有效且安全的胃肠道去污程序。
