Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.
Department of Ophthalmology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
BMC Ophthalmol. 2022 Jul 6;22(1):295. doi: 10.1186/s12886-022-02515-7.
The study aims to assess the alterations in retinal oxygen saturation and retinal and choroidal blood flow in lipemia retinalis.
This was a cross-sectional study on 10 eyes (5 patients) with history of lipemia retinalis. The study comprised 10 eyes with documented history of lipemia retinalis and 10 participants as healthy controls. Patients with a confirmed history of lipemia retinalis were grouped into two cohorts based on their most recent fundus examination: untreated lipemia retinalis (abnormal fundus) and resolved lipemia retinalis (normal fundus). Both retinal arteriolar and venular oxygen saturation were measured using the non-invasive spectrophotometric retinal oximeter (Oxymap T1). The mean blur rate (MBR) of the optic nerve and choroidal blood flow were analyzed using a laser speckle flowgraph (LSFG).
Patients with untreated lipemia retinalis had a significantly higher retinal arteriolar and venular oxygen saturation than that of the other two groups (p < 0.001). Moreover, patients with untreated lipemia retinalis had significantly smaller retinal arteriolar and venular diameters (p < 0.001). On LSFG, there was a significant difference in the overall MBR (p = 0.007) and vessel MBR of the optic nerve between the groups (p = 0.011). The patients with history of lipemia retinalis (untreated and resolved) exhibited a high overall MBR and vessel MBR of the optic nerve than that of the control group. There was a significant elevation of the optic nerve (p = 0.002) and choroidal blowout score (p < 0.001), while the resistivity index of the optic nerve (p = 0.001) and choroids (p = 0.002) was significantly lower in patients with resolved and untreated lipemia retinalis.
There was a significant alteration in retinal oximetry, in untreated lipemia retinalis, and in retinal blood flow, in both the resolved and untreated groups. The increase in retinal blood flow and oxygen saturation may elucidate the preservation of visual acuity and function despite the fundus changes observed in lipemia retinalis.
本研究旨在评估脂血症性视网膜病变中的视网膜血氧饱和度以及视网膜和脉络膜血流的变化。
这是一项横断面研究，共纳入 10 只眼（5 例患者），均有脂血症性视网膜病变病史。该研究共纳入 10 只眼，均有明确的脂血症性视网膜病变病史，同时纳入 10 例健康对照者。根据最近的眼底检查结果，将确诊为脂血症性视网膜病变的患者分为两组：未经治疗的脂血症性视网膜病变（眼底异常）和已缓解的脂血症性视网膜病变（眼底正常）。采用非侵入性光谱视网膜血氧计（Oxymap T1）测量视网膜动、静脉血氧饱和度。应用激光散斑血流图（LSFG）分析视盘平均模糊率（MBR）和脉络膜血流。
未经治疗的脂血症性视网膜病变患者的视网膜动、静脉血氧饱和度明显高于其他两组（p<0.001）。此外，未经治疗的脂血症性视网膜病变患者的视网膜动、静脉直径明显较小（p<0.001）。LSFG 结果显示，各组间总体 MBR（p=0.007）和视盘血管 MBR（p=0.011）差异均有统计学意义。有脂血症性视网膜病变病史（未经治疗和已缓解）的患者的总体 MBR 和视盘血管 MBR 均高于对照组。视神经隆起（p=0.002）和脉络膜膨出评分（p<0.001）显著升高，而视神经（p=0.001）和脉络膜（p=0.002）的阻力指数明显降低。
未经治疗的脂血症性视网膜病变和已缓解的脂血症性视网膜病变患者的视网膜血氧测量和视网膜血流均发生显著改变。视网膜血流和血氧饱和度的增加可能解释了脂血症性视网膜病变患者尽管眼底发生改变，但视力和功能仍得以保留的原因。
