National Center Chalbi Belkahia of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis, Tunisia.
Faculty of Medicine, Research unit: UR17ES12, University of Tunis El Manar, 15 Rue Djebel Lakhdhar, La Rabta, 1007, Tunis, Tunisia.
Curr Drug Saf. 2023;18(3):386-388. doi: 10.2174/1574886317666220613155550.
Flagellate erythema is a distinctive morphologic reaction pattern recognized by whiplash-like pruritic erythematous eruption. It is usually encountered in patients receiving bleomycin. Only one case of docetaxel-induced flagellate erythema is reported in the literature.
Herein, we report a rare case of docetaxel-induced flagellate erythema in a 53 years old woman with no particular medical history treated with docetaxel for metastatic adenocarcinoma of her right breast. Seven days after the third course, she developed multiple lineal and parallel pruritic erythematous streaks mainly on her chest and abdomen. The cutaneous erythema disappeared gradually over 10 days, leaving hyper-pigmented post-inflammatory linear scars lasting two weeks. The same reaction reappeared after the fourth and the fifth docetaxel course.
Flagellate erythema has been reported as an adverse drug reaction secondary to several antineoplastic molecules, including docetaxel. Further studies are needed to discover its underlying mechanisms in order to figure out better treatment plans and prevention.
鞭毛样红斑是一种独特的形态学反应模式，表现为鞭状的瘙痒性红斑疹。这种皮疹通常见于接受博来霉素治疗的患者。目前仅有一例多西紫杉醇引起的鞭毛样红斑的文献报道。
本文报告了一例罕见的 53 岁女性多西紫杉醇诱导的鞭毛样红斑病例，该患者无特殊病史，因右乳腺癌转移接受多西紫杉醇治疗。第三个疗程后 7 天，她的胸部和腹部出现了多条线性和并行的瘙痒性红斑条。皮肤红斑在 10 天内逐渐消失，留下色素沉着的线性炎症后疤痕，持续两周。第四次和第五次多西紫杉醇治疗后再次出现相同的反应。
鞭毛样红斑已被报道为多种抗肿瘤药物的不良反应，包括多西紫杉醇。需要进一步的研究来发现其潜在的机制，以便制定更好的治疗方案和预防措施。
