De Simone Veronica, Litta Francesco, Persiani Roberto, Rizzo Gianluca, Sofo Luigi, Menghi Roberta, Santullo Francesco, Biondi Alberto, Coco Claudio, Sacchetti Franco, Longo Fabio, Attalla El Halabieh Miriam, Moroni Rossana, Ratto Carlo
Proctology Unit, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
General Surgery Unit, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Front Surg. 2022 Jun 20;9:917224. doi: 10.3389/fsurg.2022.917224. eCollection 2022.
The low anterior resection syndrome (LARS) score is a validated questionnaire developed in Denmark to measure the severity of bowel dysfunction after low anterior resection. This retrospective study aimed to assess the effectiveness of the LARS score in the Italian language in a population of Italian patients who underwent low anterior resection for rectal cancer. The convergent and discriminative validity and the test-retest reliability of the score were investigated.
A cohort of two hundred and five patients treated with low anterior resection were enrolled in an Italian high-volume university hospital between January 2000 and April 2018. The Italian version of the LARS score (tested twice), as translated from English original version, a single question on quality of life and the EORTC QLQ-C30 questionnaire were submitted to patients.
A high proportion of patients showed a perfect or moderate fit between the LARS score and QoL categories (convergent validity, < 0.0005). All differences regarding the items of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 (EORTC QLQ-C30) functional scales were statistically significant ( < 0.0005). The LARS score was able to discriminate between groups of patients who received or did not receive preoperative chemoradiotherapy ( < 0.0005) and those who received total or partial mesorectal excision ( < 0.0005). The test-retest reliability was excellent (intraclass correlation coefficient 0.96).
The Italian translation of the LARS score is an easy and reliable tool for assessing bowel dysfunction after low anterior resection and its routine use in clinical practice should be recommended. at www.clinicaltrials.gov: NCT04406311.
低位前切除术综合征（LARS）评分是丹麦开发的一种经过验证的问卷，用于衡量低位前切除术后肠道功能障碍的严重程度。这项回顾性研究旨在评估意大利语版LARS评分在接受直肠癌低位前切除术的意大利患者群体中的有效性。研究了该评分的收敛效度、区分效度和重测信度。
2000年1月至2018年4月期间，在一家意大利大型大学医院招募了205例接受低位前切除术治疗的患者。将从英文原版翻译而来的意大利语版LARS评分（进行了两次测试）、一个关于生活质量的单一问题以及欧洲癌症研究与治疗组织核心30问卷（EORTC QLQ-C30）提交给患者。
很大一部分患者的LARS评分与生活质量类别之间呈现出完美或适度的契合度（收敛效度，<0.0005）。欧洲癌症研究与治疗组织生活质量问卷核心30（EORTC QLQ-C30）功能量表各项的所有差异均具有统计学意义（<0.0005）。LARS评分能够区分接受或未接受术前放化疗的患者组（<0.0005）以及接受全直肠系膜切除或部分直肠系膜切除的患者组（<0.0005）。重测信度极佳（组内相关系数为0.96）。
LARS评分的意大利语翻译是评估低位前切除术后肠道功能障碍的一种简便可靠的工具，应推荐在临床实践中常规使用。临床试验注册号：NCT04406311。
