Kim Su Hong, Kim Yae Ji, Lee Byung Hwa, Lee Peter, Park Ji Hyung, Seo Sang Won, Jeong Yong
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
KAIST Institute for Health Science Technology, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
Front Aging Neurosci. 2022 Jun 20;14:875589. doi: 10.3389/fnagi.2022.875589. eCollection 2022.
"Reserve" refers to the individual clinical differences in response to a neuropathological burden. We explored the behavioral reserve (BR) and associated neural substrates in 40 participants with behavioral variant frontotemporal dementia (bvFTD) who were assessed with the frontal behavioral inventory (FBI) and magnetic resonance imaging. Because neuroimaging abnormality showed a high negative correlation with the FBI negative (but not positive) symptom scores, we developed a linear model only to calculate the nBR (BR for negative symptoms) marker using neuroimaging abnormalities and the FBI score. Participants were divided into high nBR and low nBR groups based on the nBR marker. The FBI negative symptom score was lower in the high nBR group than in the low nBR group having the same neuroimaging abnormalities. However, the high nBR group noted a steeper decline in cortical atrophy and showed less atrophy in the left frontotemporal cortices than the low nBR group. In addition, the fractional anisotropy (FA) values were greater in the high nBR than in the low nBR group, except in the sensory-motor and occipital areas. We identified an nBR-related functional network composed of bilateral frontotemporal areas and the left occipital pole. We propose the concept of BR in bvFTD, and these findings can help predict the disease progression.
“储备”指的是个体对神经病理学负担反应的临床差异。我们对40名行为变异型额颞叶痴呆（bvFTD）患者进行了行为储备（BR）及相关神经基质的探索，这些患者接受了额叶行为量表（FBI）和磁共振成像评估。由于神经影像学异常与FBI阴性（而非阳性）症状评分呈高度负相关，我们构建了一个线性模型，仅使用神经影像学异常和FBI评分来计算nBR（阴性症状的BR）标志物。根据nBR标志物将参与者分为高nBR组和低nBR组。在具有相同神经影像学异常的情况下，高nBR组的FBI阴性症状评分低于低nBR组。然而，高nBR组的皮质萎缩下降更为明显，且与低nBR组相比，左侧额颞叶皮质的萎缩程度更小。此外，除感觉运动区和枕叶外，高nBR组的分数各向异性（FA）值大于低nBR组。我们确定了一个由双侧额颞叶区域和左侧枕极组成的与nBR相关的功能网络。我们提出了bvFTD中BR的概念，这些发现有助于预测疾病进展。
