School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom.
MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom.
PLoS Negl Trop Dis. 2022 Jul 7;16(7):e0010568. doi: 10.1371/journal.pntd.0010568. eCollection 2022 Jul.
Cystic echinococcosis (CE) is a zoonotic neglected tropical disease (zNTD) which imposes considerable financial burden to endemic countries. The 2021-2030 World Health Organization's roadmap on NTDs has proposed that intensified control be achieved in hyperendemic areas of 17 countries by 2030. Successful interventions for disease control, and the scale-up of programmes applying such interventions, rely on understanding the associated costs and relative return for investment. We conducted a scoping review of existing peer-reviewed literature on economic evaluations of CE control strategies focused on Echinococcus granulosus zoonotic hosts.
METHODOLOGY/PRINCIPAL FINDINGS: Database searches of Scopus, PubMed, Web of Science, CABI Direct and JSTOR were conducted and comprehensively reviewed in March 2022, using predefined search criteria with no date, field or language restrictions. A total of 100 papers were initially identified and assessed for eligibility against strict inclusion and exclusion criteria, following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. Bibliography review of included manuscripts was used to identify additional literature. Full review of the final manuscript selection (n = 9) was performed and cost data for control interventions were extracted.
CONCLUSIONS/SIGNIFICANCE: There are very little published data pertaining to the cost and cost effectiveness of CE control interventions targeting its zoonotic hosts. Data given for costs are often incomplete, thus we were unable to perform an economic analysis and cost effectiveness study, highlighting a pressing need for this information. There is much scope for future work in this area. More detailed information and disaggregated costings need to be collected and made available. This would increase the accuracy of any cost-effective analyses to be performed and allow for a greater understanding of the opportunity cost of healthcare decisions and resource allocation by stakeholders and policy makers for effective and cost-effective CE control.
包虫病（CE）是一种动物源性的被忽视的热带病（zNTD），给流行国家带来了相当大的财政负担。世界卫生组织 2021-2030 年关于非传染性疾病的路线图提出，到 2030 年，在 17 个流行国家的高度流行地区实现强化控制。成功的疾病控制干预措施，以及扩大实施这些干预措施的方案，依赖于了解相关成本和投资的相对回报。我们对关于包虫病控制策略的经济评估的现有同行评议文献进行了范围审查，重点是细粒棘球绦虫的动物宿主。
方法/主要发现：2022 年 3 月，我们使用预先设定的搜索标准，对 Scopus、PubMed、Web of Science、CABI Direct 和 JSTOR 数据库进行了搜索，并进行了全面审查，这些标准没有日期、领域或语言限制。根据严格的纳入和排除标准，最初确定了 100 篇论文，并对其进行了评估，以确定其是否符合条件，这是符合系统评价和荟萃分析扩展的首选报告项目（PRISMA-ScR）指南。纳入文献的参考文献综述用于确定其他文献。对最终入选论文的全文进行了全面审查（n=9），并提取了控制干预措施的成本数据。
结论/意义：针对其动物宿主的包虫病控制干预措施的成本和成本效益的出版数据非常少。提供的成本数据往往不完整，因此我们无法进行经济分析和成本效益研究，这突出表明了对此类信息的迫切需求。在这一领域有很大的工作空间。需要收集和提供更详细的信息和分类成本。这将提高将要进行的任何成本效益分析的准确性，并使利益相关者和决策者更好地了解医疗保健决策和资源分配的机会成本，以实现有效和具有成本效益的包虫病控制。
