Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL.
Med Sci Sports Exerc. 2022 Dec 1;54(12):2031-2036. doi: 10.1249/MSS.0000000000002992. Epub 2022 Jul 8.
This study aimed to determine if percent fat-free mass loss (% FFML) after diet alone, diet plus aerobic, or diet plus resistance exercise is a predictor of weight regain in women with overweight.
One hundred and forty-one premenopausal women with overweight (body mass index, 28 ± 1 kg·m -2 ; age, 35 ± 6 yr) enrolled in a weight loss program to achieve a body mass index <25 kg·m -2 (diet alone, diet plus resistance, or diet plus aerobic exercise) and were followed for 1 yr. Body weight and composition (with dual-energy x-ray absorptiometry) were measured at baseline, after weight loss, and at 1 yr.
Participants lost 12.1 ± 2.6 kg of body weight, 11.3 ± 2.5 kg of fat mass, and 0.5 ± 1.6 kg of fat-free mass during the weight loss intervention, followed by weight regain at 1 yr (6.0 ± 4.4 kg, 51.3% ± 37.8%; P < 0.001 for all). % FFML was -3.6 ± 12.4, and a greater % FFML was associated with more weight regain ( r = -0.216, P = 0.01, n = 141), even after adjusting for the intervention group ( β = -0.07; 95% confidence interval, -0.13 to -0.01; P = 0.017).
% FFML is a significant predictor of weight regain in premenopausal women with overweight. These results support strategies for conserving fat-free mass during weight loss, such as resistance training. Future research should try to identify the mechanisms, at the level of both appetite and energy expenditure, responsible for this association.
本研究旨在确定单纯饮食、饮食加有氧运动或饮食加抗阻运动后去脂体重丢失（%FFML）是否可以预测超重女性体重反弹。
141 名超重（体重指数 28±1kg·m-2，年龄 35±6 岁）的绝经前妇女参加了一项减肥计划，以达到体重指数<25kg·m-2（单纯饮食、饮食加抗阻运动或饮食加有氧运动），并随访 1 年。在基线、减肥后和 1 年时测量体重和体成分（采用双能 X 线吸收法）。
参与者在减肥干预期间体重减轻了 12.1±2.6kg，体脂减轻了 11.3±2.5kg，去脂体重减轻了 0.5±1.6kg，随后在 1 年内体重反弹（6.0±4.4kg，51.3%±37.8%；所有 P<0.001）。%FFML 为-3.6±12.4，更大的%FFML 与更多的体重反弹相关（r=-0.216，P=0.01，n=141），即使在调整干预组后（β=-0.07；95%置信区间，-0.13 至-0.01；P=0.017）。
%FFML 是超重绝经前妇女体重反弹的一个重要预测指标。这些结果支持在减肥过程中保持去脂体重的策略，如抗阻训练。未来的研究应试图确定在食欲和能量消耗水平上导致这种关联的机制。
