减肥过程中去脂体重丢失比例、食欲变化与随后体重变化之间的关联：一项随机 2 期饮食干预试验的结果。
Associations between the proportion of fat-free mass loss during weight loss, changes in appetite, and subsequent weight change: results from a randomized 2-stage dietary intervention trial.
机构信息
School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom.
School of Food Science and Nutrition, Faculty of Mathematics and Physical Sciences, University of Leeds, Leeds, United Kingdom.
出版信息
Am J Clin Nutr. 2020 Mar 1;111(3):536-544. doi: 10.1093/ajcn/nqz331.
BACKGROUND
Dynamic changes in body composition which occur during weight loss may have an influential role on subsequent energy balance behaviors and weight.
OBJECTIVES
The aim of this article is to consider the effect of proportionate changes in body composition during weight loss on subsequent changes in appetite and weight outcomes at 26 wk in individuals engaged in a weight loss maintenance intervention.
METHODS
A subgroup of the Diet, Obesity, and Genes (DiOGenes) study (n = 209) was recruited from 3 European countries. Participants underwent an 8-wk low-calorie diet (LCD) resulting in ≥8% body weight loss, during which changes in body composition (by DXA) and appetite (by visual analog scale appetite perceptions in response to a fixed test meal) were measured. Participants were randomly assigned into 5 weight loss maintenance diets based on protein and glycemic index content and followed up for 26 wk. We investigated associations between proportionate fat-free mass (FFM) loss (%FFML) during weight loss and 1) weight outcomes at 26 wk and 2) changes in appetite perceptions.
RESULTS
During the LCD, participants lost a mean ± SD of 11.2 ± 3.5 kg, of which 30.4% was FFM. After adjustment, there was a tendency for %FFML to predict weight regain in the whole group (β: 0.041; 95% CI: -0.001, 0.08; P = 0.055), which was significant in men (β: 0.09; 95% CI: 0.02, 0.15; P = 0.009) but not women (β: 0.01; 95% CI: -0.04, 0.07; P = 0.69). Associations between %FFML and change in appetite perceptions during weight loss were inconsistent. The strongest observations were in men for hunger (r = 0.69, P = 0.002) and desire to eat (r = 0.61, P = 0.009), with some tendencies in the whole group and no associations in women.
CONCLUSIONS
Our results suggest that composition of weight loss may have functional importance for energy balance regulation, with greater losses of FFM potentially being associated with increased weight regain and appetite. This trial was registered at clinicaltrials.gov as NCT00390637.
背景
减肥过程中身体成分的动态变化可能对随后的能量平衡行为和体重有影响。
目的
本文旨在探讨减肥过程中身体成分比例的变化对参与减肥维持干预的个体在 26 周时食欲和体重结果的后续变化的影响。
方法
从 3 个欧洲国家招募了 Diet，Obesity，and Genes（DiOGenes）研究的一个亚组（n=209）。参与者接受了 8 周的低热量饮食（LCD），体重减轻≥8%，在此期间通过 DXA 测量身体成分（身体无脂肪质量[FFM]和脂肪质量）的变化和食欲（通过对固定测试餐的视觉模拟量表食欲感知来测量）。参与者根据蛋白质和血糖指数含量随机分配到 5 种减肥维持饮食中，并随访 26 周。我们调查了减肥过程中比例性无脂肪质量（FFM）损失（%FFML）与 1）26 周时的体重结果和 2）食欲感知变化之间的关系。
结果
在 LCD 期间，参与者平均减轻了 11.2±3.5kg，其中 30.4%是 FFM。调整后，%FFML 有预测整个组体重反弹的趋势（β：0.041；95%CI：-0.001，0.08；P=0.055），这在男性中是显著的（β：0.09；95%CI：0.02，0.15；P=0.009），但在女性中不显著（β：0.01；95%CI：-0.04，0.07；P=0.69）。%FFML 与减肥期间食欲感知变化之间的关系不一致。在男性中，饥饿感（r=0.69，P=0.002）和想吃的欲望（r=0.61，P=0.009）的相关性最强，整个组有一些趋势，但女性没有相关性。
结论
我们的结果表明，减肥的成分可能对能量平衡调节具有功能重要性，更大的 FFM 损失可能与体重增加和食欲增加有关。该试验在 clinicaltrials.gov 上注册为 NCT00390637。
Zotero 插件