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对接受联合身体锻炼的肥胖女性的血浆进行非靶向脂质组学分析。

Untargeted lipidomic analysis of plasma from obese women submitted to combined physical exercise.

机构信息

Internal Medicine Department, Ribeirão Preto Medical School, University of São Paulo-FMRP USP, Ribeirão Preto, São Paulo, Brazil.

University State of Minas Gerais, Divinópolis, MG, Brazil.

出版信息

Sci Rep. 2022 Jul 7;12(1):11541. doi: 10.1038/s41598-022-15236-0.

DOI:10.1038/s41598-022-15236-0
PMID:35798803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9263166/
Abstract

This study aimed to determine the changes of lipidome in obese women undergoing combined physical exercise training. Fourteen adult women with obesity (mean BMI and age, 33 kg/m and 34 ± 5 years), were submitted to combined physical training (aerobic and strength exercises, alternately, 55 min at 75-90% of the maximum heart rate, 3 times a week) for 8 weeks. All participants were evaluated before and after the training intervention for lipidome, anthropometric measurements, muscle strength, and maximum oxygen consumption (VOmax). Untargeted liquid chromatography-mass spectrometry analyses allowed the identification of 1252 variables, of which 160 were significant (p < 0.05), and 61 were identified as molecular species of lipids. Volcano plot analysis revealed LPC(16:0p), LPC(18:0p), LPC(20:2), and arachidonic acid upregulated and PC(38:1p), PC(40:4), PC(40:4p) downregulated after combined physical exercise. From the results of the overall Principal component analysis (PCA), the major finding was SM(d18:1/20:0), arachidonic acid, and PC(40:6) species. Other changes included a reduction in waist circumference (Δ = - 2 cm) (p < 0.05), with no weight loss. In conclusion, 8-week of combined exercise training in obese women brought changes in different classes of lipids. This study provides further information to understand the effect of combined physical exercise on lipids related to obesity.

摘要

本研究旨在确定接受综合体能训练的肥胖女性脂质组的变化。14 名成年肥胖女性（平均 BMI 和年龄为 33kg/m 和 34±5 岁）接受了 8 周的综合体能训练（有氧运动和力量训练交替进行，最大心率的 75-90%，每周 3 次，每次 55 分钟）。所有参与者在训练干预前后均进行脂质组、人体测量学测量、肌肉力量和最大摄氧量（VOmax）评估。非靶向液相色谱-质谱分析允许鉴定 1252 个变量，其中 160 个具有统计学意义（p<0.05），并且鉴定出 61 个为脂质的分子种类。火山图分析显示 LPC(16:0p)、LPC(18:0p)、LPC(20:2)和花生四烯酸上调，PC(38:1p)、PC(40:4)、PC(40:4p)下调。从总体主成分分析（PCA）的结果来看，主要发现是 SM(d18:1/20:0)、花生四烯酸和 PC(40:6)。其他变化包括腰围减少（Δ=-2cm）（p<0.05），但体重无变化。总之，肥胖女性 8 周的综合运动训练带来了不同类脂质的变化。这项研究提供了进一步的信息，以了解综合体力活动对与肥胖相关的脂质的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc8e/9263166/8b64f28a2345/41598_2022_15236_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc8e/9263166/de1269f879e3/41598_2022_15236_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc8e/9263166/fede9e1ef769/41598_2022_15236_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc8e/9263166/003dd3c8dbf3/41598_2022_15236_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc8e/9263166/8b64f28a2345/41598_2022_15236_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc8e/9263166/de1269f879e3/41598_2022_15236_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc8e/9263166/fede9e1ef769/41598_2022_15236_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc8e/9263166/003dd3c8dbf3/41598_2022_15236_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc8e/9263166/8b64f28a2345/41598_2022_15236_Fig4_HTML.jpg

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