Kingston Health Sciences Centre, Kingston, ON, Canada.
J Cardiothorac Surg. 2022 Jul 7;17(1):172. doi: 10.1186/s13019-022-01922-7.
Complex cardiac surgery and prolonged cardiopulmonary bypass are associated with significant activation of the systemic inflammatory response system. Pro-inflammatory cytokines, oxygen free radicals and complement activation products contribute to postoperative complications and multiorgan injury. CytoSorb® hemoadsorption therapy has been suggested to alleviate the hyperinflammatory response triggered by cardiopulmonary bypass during cardiac surgery.
We describe the use of CytoSorb® hemoadsorption therapy in a 61-year-old male presenting for aortic valve replacement, mitral valve replacement, tricuspid valve repair, coronary artery bypass grafting and left atrial appendage clip.
We were able to demonstrate that CytoSorb® use during cardiopulmonary bypass may be a safe and feasible adjunct therapy that may contribute to improved postoperative outcomes in a patient with complex cardiac disease.
复杂的心脏手术和长时间的心肺体外循环会引起全身性炎症反应系统的显著激活。促炎细胞因子、氧自由基和补体激活产物会导致术后并发症和多器官损伤。细胞吸附疗法已被建议用于减轻心脏手术体外循环引发的过度炎症反应。
我们描述了一名 61 岁男性在接受主动脉瓣置换术、二尖瓣置换术、三尖瓣修复术、冠状动脉旁路移植术和左心耳夹闭术时使用 CytoSorb®血液吸附治疗的情况。
我们能够证明,在心肺体外循环期间使用 CytoSorb®可能是一种安全且可行的辅助治疗方法,可有助于复杂心脏疾病患者的术后转归改善。