Sommer A, Brewer M T, Thompson R C, Moscatelli D, Presta M, Rifkin D B
Biochem Biophys Res Commun. 1987 Apr 29;144(2):543-50. doi: 10.1016/s0006-291x(87)80001-3.
The amino acid sequence of a human placental bFGF was determined by a combination of protein and cDNA sequencing. The placental bFGF consists of 157 amino acid residues with a calculated molecular weight of 17,464 and is highly homologous to bovine pituitary bFGF. The human protein contains an amino terminal extension when compared to the sequence established for bovine bFGF (Esch et al., 1985) and to the sequence of the predicted translation product based on human bFGF cDNA clones (Abraham et al., 1986).
通过蛋白质测序和cDNA测序相结合的方法确定了人胎盘碱性成纤维细胞生长因子（bFGF）的氨基酸序列。胎盘bFGF由157个氨基酸残基组成，计算分子量为17464，与牛垂体bFGF高度同源。与已确定的牛bFGF序列（埃施等人，1985年）以及基于人bFGF cDNA克隆预测的翻译产物序列（亚伯拉罕等人，1986年）相比，人蛋白质含有一个氨基末端延伸。
