Hsieh Ming-Hong, Nfor Oswald Ndi, Ho Chien-Chang, Hsu Shu-Yi, Lee Chun-Te, Jan Cheng-Feng, Hsieh Pao-Chun, Liaw Yung-Po
School of Medicine, Chung Shan Medical University, Taichung City, Taiwan.
Department of Psychiatry, Chung Shan Medical University Hospital, Taichung City, Taiwan.
Front Psychiatry. 2022 Jun 21;13:821448. doi: 10.3389/fpsyt.2022.821448. eCollection 2022.
BACKGROUND/AIM: Recent studies reported that folate supplementation has beneficial effects on major depression. The Methylenetetrahydrofolate reductase (MTHFR) enzyme is crucial in folate metabolism. This population-based study examined the association between MTHFR rs17367504 polymorphism and major depressive disorder based on exercise habits.
Taiwan Biobank (TWB) provided demographic and genotype data between 2008 and 2015. The biobank participants were Taiwanese aged 30 to 70. Data on major depressive disorder (MDD) were obtained from the National Health Insurance Research Database (NHIRD).
A total of 636 individuals were identified with MDD, whereas 17,298 individuals were considered controls. The associations of MTHFR rs17367504 and exercise with MDD risk were estimated using logistic regression models. The distribution of MTHFR rs17367504 genotype frequencies differed significantly between the MDD and control groups. We found that, compared with the AA genotype, the GG genotype was associated with a significantly increased risk of MDD [adjusted odds ratio (aOR), 1.76; 95% confidence interval (CI), 1.05-2.94; = 0.033]. We found an interaction ( = 0.04) between rs17367504 and exercise, a well-known protective factor for MDD. A substantial increase in the risk of MDD was found among those with GG genotypes who did not exercise (aOR, 2.93; 95% CI, 1.66-5.17; < 0.001).
Our findings indicate that MDD is related to MTHFR rs17367504 and exercise, though the mechanisms remain to be determined.
背景/目的：近期研究报告称补充叶酸对重度抑郁症有有益影响。亚甲基四氢叶酸还原酶（MTHFR）在叶酸代谢中起关键作用。这项基于人群的研究基于运动习惯，探讨了MTHFR rs17367504多态性与重度抑郁症之间的关联。
台湾生物银行（TWB）提供了2008年至2015年期间的人口统计学和基因型数据。生物银行参与者为30至70岁的台湾人。重度抑郁症（MDD）数据来自国民健康保险研究数据库（NHIRD）。
共识别出636例MDD患者，17298例为对照。使用逻辑回归模型估计MTHFR rs17367504和运动与MDD风险的关联。MDD组和对照组之间MTHFR rs17367504基因型频率分布存在显著差异。我们发现，与AA基因型相比，GG基因型与MDD风险显著增加相关[调整后的优势比（aOR）为1.76；95%置信区间（CI）为1.05 - 2.94；P = 0.033]。我们发现rs17367504与运动之间存在相互作用（P = 0.04），运动是已知的MDD保护因素。在未运动的GG基因型个体中，MDD风险大幅增加（aOR为2.93；95%CI为1.66 - 5.17；P < 0.001）。
我们的研究结果表明MDD与MTHFR rs17367504和运动有关，尽管其机制仍有待确定。
